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Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery
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Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery
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Journal Article
Flexibility-tuning of dual-display DNA-encoded chemical libraries facilitates cyclic peptide ligand discovery
2025
Overview
Cyclic peptides constitute an important drug modality since they offer significant advantages over small molecules and macromolecules. However, access to diverse chemical sets of cyclic peptides is difficult on a large library scale. DNA-encoded Chemical Libraries (DELs) provide a suitable tool to obtain large chemical diversity, but cyclic DELs made by standard DEL implementation cannot efficiently explore their conformational diversity. On the other hand, dual-display Encoded Self-Assembling Chemical (ESAC) Libraries can be used for modulating macrocycle flexibility since the two displayed peptides can be connected in an incremental fashion. In this work, we construct a 56 million dual-display ESAC library using a two-step cyclization strategy. We show that varying the level of conformational restraint is essential for the discovery of specific ligands for the three protein targets thrombin, human alkaline phosphatase and streptavidin.
Cyclic peptides are an important drug modality but access to diverse chemical sets of cyclic peptides is difficult on a large library scale. Here, the authors use DNA-encoded library (DEL) technology for the dual-display of two peptidic sub-libraries at the extremities of DNA heteroduplexes and show that varying the level of conformational restraint is essential for the discovery of specific ligands for the three protein targets.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 49/98
/ 82/16
/ 82/29
/ 82/58
/ Alkaline Phosphatase - chemistry
/ Alkaline Phosphatase - metabolism
/ DNA
/ Humanities and Social Sciences
/ Humans
/ Ligands
/ Peptides
/ Peptides, Cyclic - chemistry
/ Peptides, Cyclic - metabolism
/ Proteins
/ Science
/ Small Molecule Libraries - chemistry
/ Thrombin
