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Distinct subnetworks of the mouse anterior thalamic nuclei
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Distinct subnetworks of the mouse anterior thalamic nuclei
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Journal Article
Distinct subnetworks of the mouse anterior thalamic nuclei
2025
Overview
Currently, classification of neuron types in the mouse thalamus remains largely incomplete. The anterior thalamic nuclei (ATN), a Papez circuit component, encompass the anterodorsal (AD), anteroventral (AV), and anteromedial (AM) thalamic nuclei. Structurally, the ATN facilitate communication among the neocortex, hippocampus, amygdala, and hypothalamus. Functionally, they play pivotal roles in learning, memory, spatial navigation, and goal-directed behaviors. Therefore, the ATN provide a promising avenue to investigate the relationship between structural and functional complexity with neuron type diversity. In male mice, comprehensive, systematically collected, pathway tracing data revealed several connectionally unique ATN cell populations, suggesting multiple parallel subnetworks run through each nucleus. Further, we applied genetic sparse labeling, brain clearing, 3D microscopic imaging, and computational informatics to morphologically characterize and catalog ATN neuron types. This study provides insights into how the prefrontal cortex, hippocampus, and amygdala interact through neuron type-specific ATN subnetworks to coordinate cognitive and emotional aspects of goal-directed behavior.
Neural networks fundamentally dictate function. Here, the authors show thirteen uniquely connected neuron populations within the anterior thalamic nuclei, suggesting multiple parallel subnetworks support its emotional and cognitive functions.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 14/19
/ 14/32
/ 14/34
/ 14/63
/ Amygdala
/ Animals
/ Anterior Thalamic Nuclei - cytology
/ Anterior Thalamic Nuclei - physiology
/ Humanities and Social Sciences
/ Labeling
/ Male
/ Memory
/ Mice
/ Neural Pathways - physiology
/ Neurons
/ Nuclei
/ Prefrontal Cortex - physiology
/ Science
/ Spatial discrimination learning
/ Structure-function relationships
/ Thalamus
