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Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
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Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
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Journal Article
Age-associated effect of kestose on Faecalibacterium prausnitzii and symptoms in the atopic dermatitis infants
2016
Overview
Background:
Although
Faecalibacterium prausnitzii
is a major bacterium in the intestine of adults, which is known to have anti-inflammatory effects, the development in infants or the response to prebiotics remains unclear.
Methods:
The counts of
F. prausnitzii
in the feces were examined by real-time polymerase chain reaction (PCR). Fecal samples were obtained from 65 atopic dermatitis (AD) infants who participated in a randomized controlled clinical trial to investigate the therapeutic effect of kestose, the smallest fructooligosaccharide.
Results:
Although the
F. prausnitzii
count was undetectable level in most 0- to 1-y-old infants, the count reached a level comparable to that in adults in 2- to 5-y-old infants. The bacterial number increased about 10-fold by oral administration of kestose every day for 12 wk in the younger infants, but not so much in the older infants. This bacterial increase was significantly correlated with an improvement in the AD symptoms in the older infants.
Conclusion:
The
F. prausnitzii
population in the intestine reaches a level comparable to that in adult at approximately 2 y of age. Kestose efficiently stimulates the growth of this bacterium in the intestine, which might lead to an improvement in AD symptoms in infants.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Bifidobacterium - drug effects
/ Bifidobacterium - isolation & purification
/ Dermatitis, Atopic - drug therapy
/ Dermatitis, Atopic - microbiology
/ Eczema
/ Faecalibacterium prausnitzii - drug effects
/ Faecalibacterium prausnitzii - genetics
/ Faecalibacterium prausnitzii - isolation & purification
/ Female
/ Gastrointestinal Microbiome - drug effects
/ Humans
/ Infant
/ Male
/ Oligosaccharides - therapeutic use
/ Prebiotics - administration & dosage
