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Free-Water Imaging in White and Gray Matter in Parkinson’s Disease

by Hori, Masaaki , Wada, Akihiko , Pantelis, Christos , Oyama, Genko , Kamagata, Koji , Ogawa, Takashi , Andica, Christina , Shimo, Yashushi , Suzuki, Michimasa , Aoki, Shigeki , Zalesky, Andrew , Hattori, Nobutaka , Hagiwara, Akifumi , Irie, Ryusuke , Kumamaru, Kanako K. , Hatano, Taku , Saito, Asami , Takeshige-Amano, Haruka , Umemura, Atsushi , Uchida, Wataru

in Aged / Anisotropy / Bias / Biomarkers / Brain / Degeneration / diffusion tensor imaging / Diffusion Tensor Imaging - methods / Dopamine / Female / free-water imaging / Gray Matter - diagnostic imaging / gray matter-based spatial statistics / Humans / Inflammation / Magnetic resonance imaging / Male / Middle Aged / Movement disorders / Neurodegenerative diseases / neuroinflammation / neuronal degeneration / Parkinson Disease - diagnostic imaging / Parkinson's disease / Pathology / Radiation / Registration / Statistical analysis / Substantia alba / Substantia grisea / tract-based spatial statistics / White Matter - diagnostic imaging

2019

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Free-Water Imaging in White and Gray Matter in Parkinson’s Disease

2019

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2019

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Journal Article

Free-Water Imaging in White and Gray Matter in Parkinson’s Disease

Hori, Masaaki,

Wada, Akihiko,

Pantelis, Christos,

Oyama, Genko,

Kamagata, Koji,

Ogawa, Takashi,

Andica, Christina,

Shimo, Yashushi,

Suzuki, Michimasa,

Aoki, Shigeki,

Zalesky, Andrew,

Hattori, Nobutaka,

Hagiwara, Akifumi,

Irie, Ryusuke,

Kumamaru, Kanako K.,

Hatano, Taku,

Saito, Asami,

Takeshige-Amano, Haruka,

Umemura, Atsushi,

Uchida, Wataru

2019

Overview

This study aimed to discriminate between neuroinflammation and neuronal degeneration in the white matter (WM) and gray matter (GM) of patients with Parkinson’s disease (PD) using free-water (FW) imaging. Analysis using tract-based spatial statistics (TBSS) of 20 patients with PD and 20 healthy individuals revealed changes in FW imaging indices (i.e., reduced FW-corrected fractional anisotropy (FAT), increased FW-corrected mean, axial, and radial diffusivities (MDT, ADT, and RDT, respectively) and fractional volume of FW (FW) in somewhat more specific WM areas compared with the changes of DTI indices. The region-of-interest (ROI) analysis further supported these findings, whereby those with PD showed significantly lower FAT and higher MDT, ADT, and RDT (indices of neuronal degeneration) in anterior WM areas as well as higher FW (index of neuroinflammation) in posterior WM areas compared with the controls. Results of GM-based spatial statistics (GBSS) analysis revealed that patients with PD had significantly higher MDT, ADT, and FW than the controls, whereas ROI analysis showed significantly increased MDT and FW and a trend toward increased ADT in GM areas, corresponding to Braak stage IV. These findings support the hypothesis that neuroinflammation precedes neuronal degeneration in PD, whereas WM microstructural alterations precede changes in GM.

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Publisher

MDPI AG,MDPI

Subject

/ Bias

/ Brain

/ diffusion tensor imaging