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Neuroprotection of the hypoxic-ischemic mouse brain by human CD117+CD90+CD105+ amniotic fluid stem cells
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Neuroprotection of the hypoxic-ischemic mouse brain by human CD117+CD90+CD105+ amniotic fluid stem cells
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Journal Article
Neuroprotection of the hypoxic-ischemic mouse brain by human CD117+CD90+CD105+ amniotic fluid stem cells
2018
Overview
Human amniotic fluid contains two morphologically-distinct sub-populations of stem cells with regenerative potential, spindle-shaped (SS-hAFSCs) and round-shaped human amniotic fluid stem cells (RS-hAFSCs). However, it is unclear whether morphological differences correlate with functionality, and this lack of knowledge limits their translational applications. Here, we show that SS-hAFSCs and RS-hAFSCs differ in their neuro-protective ability, demonstrating that a single contralateral injection of SS-hAFSCs into hypoxic-ischemic P7 mice conferred a 47% reduction in hippocampal tissue loss and 43–45% reduction in TUNEL-positive cells in the hippocampus and striatum 48 hours after the insult, decreased microglial activation and TGFβ1 levels, and prevented demyelination. On the other hand, RS-hAFSCs failed to show such neuro-protective effects. It is possible that SS-hAFSCs exert their neuroprotection via endoglin-dependent inhibition of TGFβ1 signaling in target cells. These findings identify a sub-population of CD117
+
CD90
+
CD105
+
stem cells as a promising source for the neuro-protection of the developing brain.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 13/100
/ 13/51
/ Animals
/ Cell- and Tissue-Based Therapy - methods
/ Corpus Striatum - metabolism
/ damage
/ Demyelinating Diseases - genetics
/ Demyelinating Diseases - metabolism
/ Demyelinating Diseases - pathology
/ Demyelinating Diseases - prevention & control
/ Endoglin
/ Humanities and Social Sciences
/ Humans
/ Hypoxia
/ Hypoxia - prevention & control
/ injury
/ Ischemia
/ Mice
/ Neuroprotection - physiology
/ Rodents
/ Science
/ Science & Technology - Other Topics
/ therapy
/ Transforming Growth Factor beta1 - genetics
