Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions

by Itoh, Hiroshi , Nishida, Akari , Watanabe, Keita , Miyamoto, Junki , Igarashi, Miki , Irie, Junichiro , Satoh-Asahara, Noriko , Kimura, Ikuo , Mukouyama, Hiromi , Tsujimoto, Gozoh , Ohue-Kitano, Ryuji

in Alternative energy / Alternative energy sources / Animals / Biological Sciences / Body weight loss / Carbohydrates / Cecum / Diet / Diet, Ketogenic / Energy metabolism / Energy shortages / Fasting / Fatty acids / G protein-coupled receptors / HEK293 Cells / High fat diet / Humans / Intestinal microflora / Ketogenesis / Ketone Bodies - metabolism / Ketones / Ligands / Lipase / Lipid metabolism / Lipid Metabolism - physiology / Lipids / Lipoprotein lipase / Lipoprotein Lipase - blood / Low carbohydrate diet / Metabolism / Mice / Mice, Inbred C57BL / Microbiota / Nutrient deficiency / Nutrition / Physiology / Preventive medicine / Receptors / Receptors, G-Protein-Coupled - genetics / Receptors, G-Protein-Coupled - physiology / Signal Transduction / Starvation / Weight loss / Weight reduction

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions

2019

Confirm

Do you wish to request the book?

Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Ketone body receptor GPR43 regulates lipid metabolism under ketogenic conditions

Itoh, Hiroshi,

Nishida, Akari,

Watanabe, Keita,

Miyamoto, Junki,

Igarashi, Miki,

Irie, Junichiro,

Satoh-Asahara, Noriko,

Kimura, Ikuo,

Mukouyama, Hiromi,

Tsujimoto, Gozoh,

Ohue-Kitano, Ryuji

2019

Overview

Ketone bodies, including β-hydroxybutyrate and acetoacetate, are important alternative energy sources during energy shortage. β-Hydroxybutyrate also acts as a signaling molecule via specific G protein-coupled receptors (GPCRs); however, the specific associated GPCRs and physiological functions of acetoacetate remain unknown. Here we identified acetoacetate as an endogenous agonist for short-chain fatty acid (SCFA) receptor GPR43 by ligand screening in a heterologous expression system. Under ketogenic conditions, such as starvation and low-carbohydrate diets, plasma acetoacetate levels increased markedly, whereas plasma and cecal SCFA levels decreased dramatically, along with an altered gut microbiota composition. In addition, Gpr43-deficient mice showed reduced weight loss and suppressed plasma lipoprotein lipase activity during fasting and eucaloric ketogenic diet feeding. Moreover, Gpr43-deficient mice exhibited minimal weight decrease after intermittent fasting. These observations provide insight into the role of ketone bodies in energy metabolism under shifts in nutrition and may contribute to the development of preventive medicine via diet and foods.

Share this book

Add to My Shelf

Publisher

National Academy of Sciences

Subject

Alternative energy

/ Alternative energy sources

/ Animals

/ Biological Sciences

/ Body weight loss

/ Carbohydrates

/ Cecum