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Space-time analysis of head and neck cancer in Asia and its 34 countries and territories (1990–2021): Implications from the Global Burden of Disease Study 2021
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Space-time analysis of head and neck cancer in Asia and its 34 countries and territories (1990–2021): Implications from the Global Burden of Disease Study 2021
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Journal Article
Space-time analysis of head and neck cancer in Asia and its 34 countries and territories (1990–2021): Implications from the Global Burden of Disease Study 2021
2025
Overview
Asia bears a disproportionate burden of head and neck cancer (HNC). This study aimed to analyze its spatial distribution and temporal trends in Asia from 1990 to 2021, projecting trends to 2030.
We performed a secondary analysis of data from the Global Burden of Disease Study (GBD) 2021, examining disability-adjusted life years (DALYs) for HNC and its five major subtypes: nasopharyngeal cancer (NPC), thyroid cancer (TC), laryngeal cancer (LC), lip and oral cavity cancer (LOC), and other pharyngeal cancer (OPC), across five Asian subregions and 34 countries/territories from 1990 to 2021. Temporal trends were evaluated using Joinpoint regression, and projections to 2030 were generated through Bayesian Age-Period-Cohort model.
From 1990 to 2021, DALYs for HNC increased in five subregions. In contrast, age-standardized DALY rates (ASDR) declined across all subregions except South Asia, with East Asia experiencing the most rapid decrease. In 2021, South Asia recorded the highest DALYs (6,412,639) and ASDR (405.82 per 100,000) for HNC. LOC was the main HNC type in most regions (32.41% - 46.23%), except East Asia, where NPC was most common (38.96%). South Asia also exhibited the highest ASDRs for LC (67.29), LOC (182.29), and OPC (93.00) per 100,000, while Southeast Asia demonstrated the highest ASDRs for NPC (50.77) and TC (18.22) per 100,000. Significant disparities in ASDR trends for HNC subtypes were observed across Asia. By 2030, South Asia is projected to maintain the highest ASDRs for HNC (394.59), LC (62.98), LOC (185.31), and OPC (95.50). East and Southeast Asia are expected to show comparable ASDRs for NPC (approximately 50.00), with Southeast Asia leading in TC ASDR (23.90).
HNC remains a significant public health challenge in Asia, with substantial heterogeneity in its subtypes across the five subregions. Implementing targeted, region-specific strategies is crucial to mitigating the disease burden.
Publisher
Public Library of Science,Public Library of Science (PLoS)
Subject
