Journal Article

Temporal order of signal propagation within and across intrinsic brain networks

Perry, Claire, Hu, Wenhan, Guo, Zhihao, Yang, Bowen, Zhang, Jianguo, Zhang, Chao, Zhao, Baotian, Veit, Mike J., Kucyi, Aaron, Sava-Segal, Clara, Zhang, Kai, Parvizi, Josef

2021

Overview

We studied the temporal dynamics of activity within and across functional MRI (fMRI)–derived nodes of intrinsic resting-state networks of the human brain using intracranial electroencephalography (iEEG) and repeated single-pulse electrical stimulation (SPES) in neurosurgical subjects implanted with intracranial electrodes. We stimulated and recorded from 2,133 and 2,372 sites, respectively, in 29 subjects. We found that N1 and N2 segments of the evoked responses are associated with intra- and internetwork communications, respectively. In a separate cognitive experiment, evoked electrophysiological responses to visual target stimuli occurred with less temporal separation across pairs of electrodes that were located within the same fMRI-defined resting-state networks compared with those located across different resting-state networks. Our results suggest intranetwork prior to internetwork information processing at the subsecond timescale.

• Publisher: National Academy of Sciences
• Subject: Adult / Auditory evoked potentials / Biological Sciences / Brain / Brain - physiology / Brain mapping / Brain Mapping - methods / Cerebral Cortex - physiology / Cognition - physiology / Cognitive ability / Data processing / EEG / Electric Stimulation / Electrical stimuli / Electrocorticography - methods / Electrodes / Electroencephalography / Electroencephalography - methods / Event-related potentials / Female / Functional magnetic resonance imaging / Humans / Information processing / Magnetic Resonance Imaging - methods / Male / Nerve Net - physiology / Networks / Neuroscience / Neurosurgery / Spatio-Temporal Analysis / Temporal variability / Visual stimuli