Journal Article

Maternally inherited peptides as strain-specific chemosignals

Agatsuma, Takeshi, Kaba, Hideto, Fujita, Hiroko, Matsunami, Hiroaki

2020

Overview

Most mammals rely on chemosensory cues for individual recognition, which is essential to many aspects of social behavior, such as maternal bonding, mate recognition, and inbreeding avoidance. Both volatile molecules and nonvolatile peptides secreted by individual conspecifics are detected by olfactory sensory neurons in the olfactory epithelium and the vomeronasal organ. The pertinent cues used for individual recognition remain largely unidentified. Here we show that nonformylated, but not N-formylated, mitochondrially encoded peptides—that is, the nine N-terminal amino acids of NADH dehydrogenases 1 and 2—can be used to convey strain-specific information among individual mice. We demonstrate that these nonformylated peptides are sufficient to induce a strain-selective pregnancy block. We also observed that the pregnancy block by an unfamiliar peptide derived from a male of a different strain was prevented by a memory formed at the time of mating with that male. Our findings also demonstrate that pregnancy-blocking chemosignals in the urine are maternally inherited, as evidenced by the production of reciprocal sons from two inbred strains and our test of their urine’s ability to block pregnancy. We propose that this link between polymorphic mitochondrial peptides and individual recognition provides the molecular means to communicate an individual’s maternal lineage and strain.

• Publisher: National Academy of Sciences
• Subject: Amino acids / Animals / Biological Sciences / Blocking / Chemoreception / Conspecifics / Epithelium / Female / Inbreeding / Intracellular Signaling Peptides and Proteins - genetics / Intracellular Signaling Peptides and Proteins - metabolism / Male / Mate recognition / Maternal behavior / Maternal Inheritance / Mice / Mice, Inbred BALB C / Mitochondria / Mitochondria - genetics / Mitochondria - metabolism / NADH / NADH Dehydrogenase - genetics / NADH Dehydrogenase - metabolism / Neuroscience / Nicotinamide adenine dinucleotide / Olfactory Bulb / Olfactory epithelium / Olfactory receptor neurons / Peptides / Peptides - genetics / Peptides - metabolism / Pheromones / Pregnancy / Recognition / Sensory neurons / Sexual Behavior, Animal / Social behavior / Species Specificity / Vomeronasal organ