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Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study
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Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study
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Journal Article
Incidence of colorectal cancer in BRCA1 and BRCA2 mutation carriers: results from a follow-up study
2014
Overview
Background:
The
BRCA1
and
BRCA2
genes confer increased susceptibility to breast and ovarian cancer and to a spectrum of other cancers. There is controversy regarding the risk of colorectal cancer conferred by germline mutations in these two genes.
Methods:
We followed 7015 women with a
BRCA
mutation for new cases of colorectal cancer. Incidence rates in carriers were compared with population-specific incidence rates, and standardised incidence ratios (SIRs) were estimated. The expected numbers of cancers were computed by multiplying person–years at risk by the appropriate age-, sex- and country-specific incidence rates from the five countries.
Results:
Twenty-one incident colorectal cancer cases were observed among all mutation carriers, compared with 23.6 cases expected. The SIR for
BRCA1
carriers was 0.92 (95% confidence interval (CI), 0.54–1.40,
P
=0.7) and for
BRCA2
carriers was 0.82 (95% CI, 0.30–1.81,
P
=0.7). The SIR for colon cancer was 3.81 (95% CI 1.77–7.23) for women below the age of 50 years (both genes combined) and was 0.60 (95% CI 0.33–1.00) for women aged 50 years and above.
Conclusion:
The risk of colorectal cancer is increased in female carriers of
BRCA1
mutations below the age of 50 years but not in women with BRCA2 mutations or in older women.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Colorectal Neoplasms - epidemiology
/ Colorectal Neoplasms - genetics
/ Female
/ Gastroenterology. Liver. Pancreas. Abdomen
/ Genetic Predisposition to Disease
/ Humans
/ Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
/ Mutation
/ Oncology
/ Risk
/ Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
/ Tumors
