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Obesity changes the human gut mycobiome
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Journal Article
Obesity changes the human gut mycobiome
2015
Overview
The human intestine is home to a diverse range of bacterial and fungal species, forming an ecological community that contributes to normal physiology and disease susceptibility. Here, the fungal microbiota (mycobiome) in obese and non-obese subjects was characterized using Internal Transcribed Spacer (ITS)-based sequencing. The results demonstrate that obese patients could be discriminated by their specific fungal composition, which also distinguished metabolically “healthy” from “unhealthy” obesity. Clusters according to genus abundance co-segregated with body fatness, fasting triglycerides and HDL-cholesterol. A preliminary link to metabolites such as hexadecanedioic acid, caproic acid and N-acetyl-L-glutamic acid was also found.
Mucor racemosus
and
M. fuscus
were the species more represented in non-obese subjects compared to obese counterparts. Interestingly, the decreased relative abundance of the
Mucor
genus in obese subjects was reversible upon weight loss. Collectively, these findings suggest that manipulation of gut mycobiome communities might be a novel target in the treatment of obesity.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aspergillus - classification
/ Aspergillus - growth & development
/ Candida - growth & development
/ Diseases
/ Fasting
/ Female
/ Gastrointestinal Microbiome - genetics
/ Humanities and Social Sciences
/ Humans
/ Male
/ Mucor - growth & development
/ Mycological Typing Techniques
/ Obesity
/ Penicillium - classification
/ Penicillium - growth & development
/ Saccharomyces - classification
/ Saccharomyces - growth & development
/ Science
