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Synthesis and systematic review of reported neonatal SARS-CoV-2 infections
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Synthesis and systematic review of reported neonatal SARS-CoV-2 infections
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Journal Article
Synthesis and systematic review of reported neonatal SARS-CoV-2 infections
2020
Overview
A number of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections have been reported in neonates. Here, we aim to clarify the transmission route, clinical features and outcomes of these infections. We present a meta-analysis of 176 published cases of neonatal SARS-CoV-2 infections that were defined by at least one positive nasopharyngeal swab and/or the presence of specific IgM. We report that 70% and 30% of infections are due to environmental and vertical transmission, respectively. Our analysis shows that 55% of infected neonates developed COVID-19; the most common symptoms were fever (44%), gastrointestinal (36%), respiratory (52%) and neurological manifestations (18%), and lung imaging was abnormal in 64% of cases. A lack of mother–neonate separation from birth is associated with late SARS-CoV-2 infection (OR 4.94 (95% CI: 1.98–13.08),
p
= 0.0002; adjusted OR 6.6 (95% CI: 2.6–16),
p
< 0.0001), while breastfeeding is not (OR 0.35 (95% CI: 0.09–1.18),
p
= 0.10; adjusted OR 2.2 (95% CI: 0.7–6.5),
p
= 0.148). Our findings add to the literature on neonatal SARS-CoV-2 infections.
There are a growing number of reports of neonatal SARS-CoV-2 infections. Here, De Luca and colleagues systematically analyse 176 published cases to better understand the route of transmission, as well as the clinical features and outcomes of neonatal COVID-19.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ Betacoronavirus - immunology
/ Betacoronavirus - isolation & purification
/ Coronavirus Infections - diagnosis
/ Coronavirus Infections - epidemiology
/ Coronavirus Infections - pathology
/ Coronavirus Infections - transmission
/ COVID-19
/ Female
/ Humanities and Social Sciences
/ Humans
/ Maternal Exposure - adverse effects
/ Pneumonia, Viral - diagnosis
/ Pneumonia, Viral - epidemiology
/ Pneumonia, Viral - pathology
/ Pneumonia, Viral - transmission
/ Science
