Asset Details
Do you wish to reserve the book?
In vitro screening of ovarian tumor specific peptides from a phage display peptide library
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
In vitro screening of ovarian tumor specific peptides from a phage display peptide library
Do you wish to request the book?
In vitro screening of ovarian tumor specific peptides from a phage display peptide library
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
In vitro screening of ovarian tumor specific peptides from a phage display peptide library
2011
Overview
To develop more biomarkers for diagnosis and therapy of ovarian cancer, a 12-mer phage display library was used to isolate peptides that bound specifically to the human ovarian tumor cell line SK-OV-3. After five rounds of in vitro screening, the recovery rate of phages showed a 69-fold increase over the first round of washings and a group of phage clones capable of binding to SK-OV-3 cells were obtained. A phage clone named Z1 with high affinity and specificity to SK-OV-3 cells was identified in vitro. More importantly, the synthetic biotin-labeled peptide, ZP1 (=SVSVGMKPSPRP), which corresponded to the sequence of the inserted fragment of Z1, demonstrated a high specificity to SK-OV-3 cells especially when compared to other cell lines (A2780 and 3T3). ZP1 might therefore be a biomarker for targeting drug delivery in ovarian cancer therapy.
Publisher
Springer-Verlag,Springer Netherlands,Springer,Springer Nature B.V
Subject
/ Antigens, Neoplasm - analysis
/ Biological and medical sciences
/ Biomarkers, Tumor - analysis
/ Biomedical and Life Sciences
/ Biotin
/ Cancer
/ drugs
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Ovarian Neoplasms - diagnosis
/ Peptides
/ Peptides - isolation & purification
/ Phage
/ Therapy
/ Tumors
