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Rapid genome sequencing in hospitals to identify potential vaccine-escape SARS-CoV-2 variants
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Rapid genome sequencing in hospitals to identify potential vaccine-escape SARS-CoV-2 variants
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Journal Article
Rapid genome sequencing in hospitals to identify potential vaccine-escape SARS-CoV-2 variants
2021
Overview
SARS-CoV-2 genome sequencing is embedded in academic and public health laboratories, but whether there are benefits to rapid sequencing in front-line hospital laboratories is unclear. [...]we did PCR-based genotyping of all new SARS-CoV-2 cases for three south London hospitals (Guy's and St Thomas', King's College, and Princess Royal University) using the AusDiagnostics SARS-CoV-2 Typing Panel (16-well) on the AusDiagnostics HighPlex, sequencing any non-typeable results. Previous studies have shown the ability of this technology to provide sequencing data in 24 h.8 This workflow can complete in 8 h, allowing whole-genome sequencing and variant reporting to be completed on the same day as sample positivity.
Publisher
Elsevier Ltd,Elsevier Limited
