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Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
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Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
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Journal Article
Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
2004
Overview
Studies
in vitro
and in animal models of colorectal and hepatocellular cancers suggest that curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether oral administration of curcumin results in concentrations of the agent in normal and malignant human liver tissue, which are sufficient to elicit pharmacological activity. In total, 12 patients with hepatic metastases from colorectal cancer received 450–3600 mg of curcumin daily, for 1 week prior to surgery. Levels of curcumin and its metabolites were measured by HPLC in portal and peripheral blood, bile and liver tissue. Curcumin was poorly available, following oral administration, with low nanomolar levels of the parent compound and its glucuronide and sulphate conjugates found in the peripheral or portal circulation. While curcumin was not found in liver tissue, trace levels of products of its metabolic reduction were detected. In patients who had received curcumin, levels of malondialdehyde-DNA (M
1
G) adduct, which reflect oxidative DNA changes, were not decreased in post-treatment normal and malignant liver tissue when compared to pretreatment samples. The results suggest that doses of curcumin required to furnish hepatic levels sufficient to exert pharmacological activity are probably not feasible in humans.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adult
/ Aged
/ Anticarcinogenic Agents - pharmacokinetics
/ Biological and medical sciences
/ Biomedical and Life Sciences
/ Chromatography, High Pressure Liquid
/ Clinical
/ Colorectal Neoplasms - metabolism
/ Colorectal Neoplasms - pathology
/ Female
/ Humans
/ Liver
/ Liver Neoplasms - metabolism
/ Male
/ Malondialdehyde - metabolism
/ Oncology
/ Tumors
