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The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate
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The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate
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Journal Article
The TatD-like DNase of Plasmodium is a virulence factor and a potential malaria vaccine candidate
2016
Overview
Neutrophil extracellular traps (NETs), composed primarily of DNA and proteases, are released from activated neutrophils and contribute to the innate immune response by capturing pathogens.
Plasmodium falciparum
, the causative agent of severe malaria, thrives in its host by counteracting immune elimination. Here, we report the discovery of a novel virulence factor of
P. falciparum
, a TatD-like DNase (PfTatD) that is expressed primarily in the asexual blood stage and is likely utilized by the parasite to counteract NETs. PfTatD exhibits typical deoxyribonuclease activity, and its expression is higher in virulent parasites than in avirulent parasites. A
P. berghei
TatD-knockout parasite displays reduced pathogenicity in mice. Mice immunized with recombinant TatD exhibit increased immunity against lethal challenge. Our results suggest that the TatD-like DNase is an essential factor for the survival of malarial parasites in the host and is a potential malaria vaccine candidate.
Neutrophil extracellular traps (NETs), composed of DNA and proteases, contribute to the innate immune response by capturing pathogens. Here, Chang
et al
. identify a NET-degrading DNase in
Plasmodium
parasites and show that immunization with this protein provides protective immunity in a malaria mouse model.
