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Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis
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Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis
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Journal Article
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis
2016
Overview
Group 2 innate lymphoid cells (ILC2s) have an important role in acute allergic lung inflammation. Given their distribution and function, lung ILC2s are hypothesized to coordinate epithelial responses to the external environment; however, how barrier surveillance is linked to ILC2 activation remains unclear. Here, we demonstrate that alveolar type II cells are the main source of interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) generated in response to chitin or migratory helminths. IL-33 and TSLP synergistically induce an interferon regulatory factor 4 (IRF4)-IL-9 program in ILC2s, and autocrine IL-9 promotes rapid IL-5 and IL-13 production required for optimal epithelial responses in the conducting airways. Thus, ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organizational hierarchies in other organs.
Publisher
Elsevier Inc,Nature Publishing Group US,Elsevier Limited,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ Bronchoalveolar Lavage Fluid - chemistry
/ Chitin
/ Epithelial Cells - immunology
/ Epithelial Cells - parasitology
/ Interferon Regulatory Factors - genetics
/ Interferon Regulatory Factors - immunology
/ Mice
/ Nippostrongylus - immunology
/ Nippostrongylus - parasitology
/ Pneumonia - chemically induced
/ Respiratory Mucosa - immunology
/ Respiratory Mucosa - parasitology
/ Strongylida Infections - genetics
/ Strongylida Infections - immunology
/ Strongylida Infections - parasitology
