Journal Article

Association between sensitivity to thyroid hormones and trabecular bone score in euthyroid individuals: a population-based cross-sectional study

Chen, Zihan, Li, Naishi, Li, Yuanmeng, Chen, Yuxiong, Xia, Weibo, Leng, Zhiwei

2024

Overview

Background Thyroid hormone is a known pivotal factor that affects bone metabolism; however, whether bone microarchitecture is associated with thyroid hormone sensitivity is poorly understood. The trabecular bone score (TBS) serves as an essential indicator for assessing bone microarchitecture. This study aimed to investigate the relationship between sensitivity to thyroid hormones and TBS in euthyroid individuals. Methods This cross-sectional study involved 3320 euthyroid participants from the National Health and Nutrition Examination Survey (NHANES) 2007–2008. Data, including thyroid function, TBS and other related parameters, were extracted and analyzed. The indices of thyroid hormone sensitivity, including the thyrotropin thyroxine resistance index (TT4RI), thyroid-stimulating hormone index (TSHI), thyroid feedback quantile-based index (TFQI) and parametric thyroid feedback quantile-based index (PTFQI), were calculated. Greater values of these indicators indicated a greater degree of impaired thyroid hormone sensitivity. Results Impaired sensitivity to thyroid hormones was associated with degraded bone microarchitecture following adjustments for confounding variables (TT4RI: P  = 0.005, TSHI: P  = 0.008, TFQI: P  = 0.003 and PTFQI: P  = 0.006). The restricted cubic spline model demonstrated a positive relationship between TT4RI, TSHI, TFQI, PTFQI and degraded bone microarchitecture. Similar findings were observed in the analysis of subgroups stratified by age, sex, race, diabetes status, hypertension status and hyperuricemia status. Conclusions In euthyroid individuals, impaired sensitivity to thyroid hormones is associated with degraded bone microarchitecture. However, further studies are required to confirm this relationship.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: Adult / Aged / Blood pressure / Body mass index / Bone density / Bone Density - physiology / Bone microarchitecture / Bone turnover / Cancellous bone / Cancellous Bone - diagnostic imaging / Cholesterol / Cross-Sectional Studies / Diabetes / Diabetes mellitus / Diagnosis / Disease prevention / Epidemiology / Euthyroid / Feedback / Female / Females / Fractures / Health aspects / Health surveys / Hormone replacement therapy / Humans / Hyperlipidemia / Hypertension / Hyperuricemia / Hypothalamus / Immunoassay / Internal Medicine / Male / Measurement / Medicine / Medicine & Public Health / Metabolism / Middle Aged / Nutrition Surveys / Orthopedics / Osteoporosis / Parametric statistics / Population studies / Population-based studies / Rehabilitation / Rheumatology / Risk factors / Self report / Sensitivity to thyroid hormones / Smoking / Sports Medicine / Statistics / Thyroid Function Tests / Thyroid gland / Thyroid Gland - diagnostic imaging / Thyroid hormones / Thyroid Hormones - blood / Thyroid-stimulating hormone / Thyrotropin - blood / Thyroxine / Thyroxine - blood / Trabecular bone score