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Stop or Not: Genome-Wide Profiling of Reassigned Stop Codons in Ciliates
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Stop or Not: Genome-Wide Profiling of Reassigned Stop Codons in Ciliates
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Stop or Not: Genome-Wide Profiling of Reassigned Stop Codons in Ciliates
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Journal Article
Stop or Not: Genome-Wide Profiling of Reassigned Stop Codons in Ciliates
2023
Overview
Abstract
Bifunctional stop codons that have both translation and termination functions in the same species are important for understanding the evolution and function of genetic codes in living organisms. Considering the high frequency of bifunctional codons but limited number of available genomes in ciliates, we de novo sequenced seven representative ciliate genomes to explore the evolutionary history of stop codons. We further propose a stop codon reassignment quantification method (stopCR) that can identify bifunctional codons and measure their frequencies in various eukaryotic organisms. Using our newly developed method, we found two previously undescribed genetic codes, illustrating the prevalence of bifunctional stop codons in ciliates. Overall, evolutionary genomic analyses suggest that gain or loss of reassigned stop codons in ciliates is shaped by their living environment, the eukaryotic release factor 1, and suppressor tRNAs. This study provides novel clues about the functional diversity and evolutionary history of stop codons in eukaryotic organisms.
