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Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

by Eropkin, Mikhail Y. , Skepner, Eugene , Spronken, Monique I. J. , Rimmelzwaan, Guus F. , Hurt, Aeron C. , Lewis, Nicola S. , Russell, Colin A. , Osterhaus, Albert D. M. E. , Fouchier, Ron A. M. , Burke, David F. , Koel, Björn F. , Bestebroer, Theo M. , van der Vliet, Stefan , Zondag, Gerben C. M. , Smith, Derek J. , de Jong, Jan C. , Barr, Ian G. , Vervaet, Gaby

in Amino acid substitution / Amino Acid Substitution - genetics / Amino Acid Substitution - immunology / Amino acids / Antibodies / antigenic variation / Antigens / Antigens, Viral - genetics / Antigens, Viral - immunology / Binding sites / Binding Sites - genetics / Drift / Evolution / Evolution, Molecular / Evolutionary biology / Ferrets / Hemagglutinin Glycoproteins, Influenza Virus - genetics / Hemagglutinin Glycoproteins, Influenza Virus - immunology / hemagglutinins / Humans / Immune system / Immune systems / Influenza / Influenza A virus / Influenza A Virus, H3N2 Subtype - genetics / Influenza A Virus, H3N2 Subtype - immunology / Mutation / Neurons / Orthomyxoviridae / Phenotypes / Reactivity / Receptors / Viruses

2013

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Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

2013

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Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

2013

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Journal Article

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

Eropkin, Mikhail Y.,

Skepner, Eugene,

Spronken, Monique I. J.,

Rimmelzwaan, Guus F.,

Hurt, Aeron C.,

Lewis, Nicola S.,

Russell, Colin A.,

Osterhaus, Albert D. M. E.,

Fouchier, Ron A. M.,

Burke, David F.,

Koel, Björn F.,

Bestebroer, Theo M.,

van der Vliet, Stefan,

Zondag, Gerben C. M.,

Smith, Derek J.,

de Jong, Jan C.,

Barr, Ian G.,

Vervaet, Gaby

2013

Overview

The molecular basis of antigenic drift was determined for the hemagglutinin (HA) of human influenza A/H3N2 virus. From 1968 to 2003, antigenic change was caused mainly by single amino acid substitutions, which occurred at only seven positions in HA immediately adjacent to the receptor binding site. Most of these substitutions were involved in antigenic change more than once. Equivalent positions were responsible for the recent antigenic changes of influenza B and A/H1N1 viruses. Substitution of a single amino acid at one of these positions substantially changed the virus-specific antibody response in infected ferrets. These findings have potentially far-reaching consequences for understanding the evolutionary mechanisms that govern influenza viruses.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Amino acid substitution

/ Amino Acid Substitution - genetics

/ Amino Acid Substitution - immunology

/ Amino acids

/ Antibodies

/ antigenic variation

/ Antigens