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Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

by Kalil, Andre C , Arguinchona, Henry , Beigel, John H , Taylor, Barbara S , Mularski, Richard A , Jackson, Patrick E.H , Ponce, Philip O , Patterson, Thomas F , Jain, Mamta K , Cohen, Stuart H , Engemann, John J , de Bono, Stephanie , Billings, Joanne , Ruiz-Palacios, Guillermo M , Ahuja, Neera , Sandkovsky, Uriel , Ferreira, Jennifer , Tan, Seow Y , Makowski, Mat , Tomashek, Kay M , Deye, Gregory A , Lye, David C , Elie, Marie-Carmelle , Green, Michelle , Wolfe, Cameron R , Oh, Myoung-don , Rouphael, Nadine G , Sweeney, Daniel A , Cardoso, Anabela , Regalado Pineda, Justino , Kim, Eu-Suk , Kline, Susan , Cantos, Valeria D , Burgess, Timothy H , Finberg, Robert W , Tapson, Victor , Marconi, Vincent C , Davey, Richard T , Luetkemeyer, Anne F , Dempsey, Walla , El Sahly, Hana M , Dodd, Lori E , Ko, Emily R , Saklawi, Youssef , Branche, Angela R , Larson, LuAnn , Iovine, Nicole M , Bonnett, Tyler , Nayak, Seema U , Frank, Maria , Proschan, Michael , Amin, Alpesh N , Ghazaryan, Varduhi , Paules, Catharine I , Watanabe, Miki , Mehta, Aneesh K , Hsieh, Lanny , Erdmann, Nathaniel , Taiwo, Babafemi , Nielsen, Henrik

in Adenosine Monophosphate - adverse effects / Adenosine Monophosphate - analogs & derivatives / Adenosine Monophosphate - therapeutic use / Adult / Adverse events / Aged / Alanine - adverse effects / Alanine - analogs & derivatives / Alanine - therapeutic use / Antiviral Agents - adverse effects / Antiviral Agents - therapeutic use / Azetidines - adverse effects / Azetidines - therapeutic use / Clinical trials / Coronaviruses / COVID-19 / COVID-19 - drug therapy / COVID-19 - mortality / COVID-19 - therapy / Cytokines / Design / Disease / Double-Blind Method / Drug Therapy, Combination / Female / Hospital Mortality / Hospitalization / Humans / Hypersensitivity / Infectious diseases / Janus kinase / Janus Kinase Inhibitors - adverse effects / Janus Kinase Inhibitors - therapeutic use / Kinases / Male / Middle Aged / Mortality / Original / Oxygen / Oxygen Inhalation Therapy / Patients / Placebos / Purines - adverse effects / Purines - therapeutic use / Pyrazoles - adverse effects / Pyrazoles - therapeutic use / Respiration, Artificial / Severe acute respiratory syndrome coronavirus 2 / Statistical analysis / Sulfonamides - adverse effects / Sulfonamides - therapeutic use / Testing / Treatment Outcome / Ventilation

2021

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Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

2021

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2021

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Journal Article

Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19

Kalil, Andre C,

Arguinchona, Henry,

Beigel, John H,

Taylor, Barbara S,

Mularski, Richard A,

Jackson, Patrick E.H,

Ponce, Philip O,

Patterson, Thomas F,

Jain, Mamta K,

Cohen, Stuart H,

Engemann, John J,

de Bono, Stephanie,

Billings, Joanne,

Ruiz-Palacios, Guillermo M,

Ahuja, Neera,

Sandkovsky, Uriel,

Ferreira, Jennifer,

Tan, Seow Y,

Makowski, Mat,

Tomashek, Kay M,

Deye, Gregory A,

Lye, David C,

Elie, Marie-Carmelle,

Green, Michelle,

Wolfe, Cameron R,

Oh, Myoung-don,

Rouphael, Nadine G,

Sweeney, Daniel A,

Cardoso, Anabela,

Regalado Pineda, Justino,

Kim, Eu-Suk,

Kline, Susan,

Cantos, Valeria D,

Burgess, Timothy H,

Finberg, Robert W,

Tapson, Victor,

Marconi, Vincent C,

Davey, Richard T,

Luetkemeyer, Anne F,

Dempsey, Walla,

El Sahly, Hana M,

Dodd, Lori E,

Ko, Emily R,

Saklawi, Youssef,

Branche, Angela R,

Larson, LuAnn,

Iovine, Nicole M,

Bonnett, Tyler,

Nayak, Seema U,

Frank, Maria,

Proschan, Michael,

Amin, Alpesh N,

Ghazaryan, Varduhi,

Paules, Catharine I,

Watanabe, Miki,

Mehta, Aneesh K,

Hsieh, Lanny,

Erdmann, Nathaniel,

Taiwo, Babafemi,

Nielsen, Henrik

2021

Overview

In a trial involving 1033 patients hospitalized with Covid-19, the addition of baricitinib to remdesivir was associated with shorter recovery time, particularly among patients receiving high-flow oxygen, and with a 30% higher odds of improvement at day 15 than remdesivir alone. Adverse events were less frequent with the combination therapy.

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Publisher

Massachusetts Medical Society

Subject

Adenosine Monophosphate - adverse effects

/ Adenosine Monophosphate - analogs & derivatives

/ Adenosine Monophosphate - therapeutic use

/ Adult

/ Adverse events

/ Aged

/ Alanine - adverse effects