Journal Article

Chronic insomnia, high trait anxiety and their comorbidity as risk factors for incident type 2 diabetes mellitus

Bordeaux population health (BPH) ; Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Fezeu, Léopold, K, Chambaron, Stéphanie, Duquenne, Pauline, Galan, Pilar, Hercberg, Serge, Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques (CRESS (U1153 / UMR_A 1125)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Brindisi, Marie-Claude, Touvier, Mathilde, Kesse-Guyot, Emmanuelle, Hôpital Hôtel-Dieu [Paris] ; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Dijon ; Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Léger, Damien, Sommeil-Vigilance-Fatigue et Santé Publique (VIFASOM (URP_7330)) ; Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA)-U

2024

Overview

The main objective of this study was to evaluate the association of the insomnia-anxiety comorbidity with incident type 2 diabetes (T2D) in a large prospective cohort. We selected adults without diabetes at baseline from the French NutriNet-Santé cohort who had completed the trait anxiety subscale of the Spielberger State-Trait Anxiety Inventory (STAI-T, 2013–2016) and a sleep questionnaire (2014); insomnia was defined according to established criteria. Using multivariable Cox models, we compared T2D risk across 4 groups: no insomnia or anxiety (reference), insomnia alone, anxiety alone (STAI-T ≥ 40), and comorbid anxiety and insomnia. Among 35,014 participants (mean baseline age: 52.4 ± 14.0 years; 76% women), 378 (1.1%) developed T2D over a mean follow-up of 5.9 ± 2.1 years. Overall, 28.5% of the sample had anxiety alone, 7.5%—insomnia alone, and 12.5%—both disorders. In the fully-adjusted model, a higher T2D risk was associated with anxiety-insomnia comorbidity (HR = 1.40; 95% CI 1.01, 1.94), but not with each disorder separately, compared to the group without insomnia or anxiety. The findings supported a positive association between anxiety-insomnia comorbidity and incident T2D among general-population adults. Future research using clinical diagnoses of mental disorders could confirm the findings and guide diabetes prevention programs.

• Publisher: Nature Publishing Group,CCSD,Nature Publishing Group UK,Nature Portfolio
• Subject: 692/699/2743/137 / 692/699/476/1300 / Adult / Aged / Anxiety / Anxiety - epidemiology / Comorbidity / Diabetes / Diabetes mellitus / Diabetes mellitus (non-insulin dependent) / Diabetes Mellitus, Type 2 - complications / Diabetes Mellitus, Type 2 - epidemiology / Diabetes Mellitus, Type 2 - psychology / Female / Humanities and Social Sciences / Humans / Incidence / Insomnia / Life Sciences / Male / Mental disorders / Mental health / Middle Aged / multidisciplinary / Prospective Studies / Prospective study / Risk Factors / Santé publique et épidémiologie / Science / Science (multidisciplinary) / Sleep disorders / Sleep Initiation and Maintenance Disorders - epidemiology / Surveys and Questionnaires
• ISBN: 0012334229000