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Matching on provider is risky
by
Walker, Alexander M.
in
Aminocaproates - administration & dosage
/ Aminocaproates - therapeutic use
/ Amplification bias
/ Aprotinin - administration & dosage
/ Aprotinin - therapeutic use
/ Bias
/ Comparative effectiveness research
/ Comparative Effectiveness Research - methods
/ Confounding Factors (Epidemiology)
/ Coronary Artery Bypass - methods
/ Coronary Artery Bypass - mortality
/ Coronary vessels
/ Data Interpretation, Statistical
/ Epidemiology
/ Estimates
/ Hemostatics - administration & dosage
/ Hemostatics - therapeutic use
/ Hospitals
/ Humans
/ Instrumental variables
/ Internal Medicine
/ Logistics
/ Matched-Pair Analysis
/ Matching
/ Medical research
/ Mortality
/ Observational studies
/ Patient Selection
/ Patients
/ Pseudorandomization
/ Randomized Controlled Trials as Topic
/ Reproducibility of Results
/ Research Design
/ Studies
/ Unmeasured confounders
/ Z-bias
2013
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Matching on provider is risky
by
Walker, Alexander M.
in
Aminocaproates - administration & dosage
/ Aminocaproates - therapeutic use
/ Amplification bias
/ Aprotinin - administration & dosage
/ Aprotinin - therapeutic use
/ Bias
/ Comparative effectiveness research
/ Comparative Effectiveness Research - methods
/ Confounding Factors (Epidemiology)
/ Coronary Artery Bypass - methods
/ Coronary Artery Bypass - mortality
/ Coronary vessels
/ Data Interpretation, Statistical
/ Epidemiology
/ Estimates
/ Hemostatics - administration & dosage
/ Hemostatics - therapeutic use
/ Hospitals
/ Humans
/ Instrumental variables
/ Internal Medicine
/ Logistics
/ Matched-Pair Analysis
/ Matching
/ Medical research
/ Mortality
/ Observational studies
/ Patient Selection
/ Patients
/ Pseudorandomization
/ Randomized Controlled Trials as Topic
/ Reproducibility of Results
/ Research Design
/ Studies
/ Unmeasured confounders
/ Z-bias
2013
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Matching on provider is risky
by
Walker, Alexander M.
in
Aminocaproates - administration & dosage
/ Aminocaproates - therapeutic use
/ Amplification bias
/ Aprotinin - administration & dosage
/ Aprotinin - therapeutic use
/ Bias
/ Comparative effectiveness research
/ Comparative Effectiveness Research - methods
/ Confounding Factors (Epidemiology)
/ Coronary Artery Bypass - methods
/ Coronary Artery Bypass - mortality
/ Coronary vessels
/ Data Interpretation, Statistical
/ Epidemiology
/ Estimates
/ Hemostatics - administration & dosage
/ Hemostatics - therapeutic use
/ Hospitals
/ Humans
/ Instrumental variables
/ Internal Medicine
/ Logistics
/ Matched-Pair Analysis
/ Matching
/ Medical research
/ Mortality
/ Observational studies
/ Patient Selection
/ Patients
/ Pseudorandomization
/ Randomized Controlled Trials as Topic
/ Reproducibility of Results
/ Research Design
/ Studies
/ Unmeasured confounders
/ Z-bias
2013
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Journal Article
Matching on provider is risky
2013
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Overview
To illustrate that matching on provider may exacerbate, not remove, bias.
The degree of confounding bias depends in part on the proportions of treatment variation that can be ascribed to confounders and to instruments, respectively. This commentary raises the specific example of bias by matching on hospital induced in a study of coronary artery bypass graft surgery patients and illustrates the effect of matching on provider in a constructed example.
Matching on provider removes a “benign” source of treatment variability, leaving unmeasured confounders as potentially the most important determinants of treatment.
Researchers need to articulate the presumed source of pseudorandom variation in observational studies and need to take care not to reduce their effect through unnecessary control.
Publisher
Elsevier Inc,Elsevier Limited
Subject
Aminocaproates - administration & dosage
/ Aminocaproates - therapeutic use
/ Aprotinin - administration & dosage
/ Bias
/ Comparative effectiveness research
/ Comparative Effectiveness Research - methods
/ Confounding Factors (Epidemiology)
/ Coronary Artery Bypass - methods
/ Coronary Artery Bypass - mortality
/ Data Interpretation, Statistical
/ Hemostatics - administration & dosage
/ Hemostatics - therapeutic use
/ Humans
/ Matching
/ Patients
/ Randomized Controlled Trials as Topic
/ Studies
/ Z-bias
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