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PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
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PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
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PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
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Journal Article
PET/MRI of glucose metabolic rate, lipid content and perfusion in human brown adipose tissue
2021
Overview
This study evaluated the MRI-derived fat fraction (FF), from a Cooling-reheating protocol, for estimating the cold-induced brown adipose tissue (BAT) metabolic rate of glucose (MR
glu
) and changes in lipid content, perfusion and arterial blood volume (V
A
) within cervical-supraclavicular fat (sBAT). Twelve volunteers underwent PET/MRI at baseline, during cold exposure and reheating. For each temperature condition, perfusion and V
A
were quantified with dynamic [
15
O]water-PET, and FF, with water-fat MRI. MR
glu
was assessed with dynamic [
18
F]fluorodeoxyglucose-PET during cold exposure. sBAT was defined using anatomical criteria, and its subregion sBAT
HI
, by MR
glu
> 11 μmol/100 cm
3
/min. For all temperature conditions, sBAT-FF correlated negatively with sBAT-MR
glu
(ρ ≤ − 0.87). After 3 h of cold, sBAT-FF decreased (− 2.13 percentage points) but tended to normalize during reheating although sBAT
HI
-FF remained low. sBAT-perfusion and sBAT-V
A
increased during cold exposure (perfusion: + 5.2 ml/100 cm
3
/min, V
A
: + 4.0 ml/100 cm
3
). sBAT-perfusion remained elevated and sBAT-V
A
normalized during reheating. Regardless of temperature condition during the Cooling-reheating protocol, sBAT-FF could predict the cold-induced sBAT-MR
glu
. The FF decreases observed after reheating were mainly due to lipid consumption, but could potentially be underestimated due to intracellular lipid replenishment. The influence of perfusion and V
A
, on the changes in FF observed during cold exposure, could not be ruled out.
