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Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
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Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
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Journal Article
Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
2008
Overview
Bacterial infection often results in the formation of tissue abscesses, which represent the primary site of interaction between invading bacteria and the innate immune system. We identify the host protein calprotectin as a neutrophil-dependent factor expressed inside Staphylococcus aureus abscesses. Neutrophil-derived calprotectin inhibited S. aureus growth through chelation of nutrient Mn²⁺ and Zn²⁺: an activity that results in reprogramming of the bacterial transcriptome. The abscesses of mice lacking calprotectin were enriched in metal, and staphylococcal proliferation was enhanced in these metal-rich abscesses. These results demonstrate that calprotectin is a critical factor in the innate immune response to infection and define metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Animals
/ Bacteria
/ Biological and medical sciences
/ Chelating Agents - metabolism
/ Chelating Agents - pharmacology
/ Kidney Diseases - immunology
/ Kidney Diseases - metabolism
/ Kidney Diseases - microbiology
/ Kidneys
/ Leukocyte L1 Antigen Complex - genetics
/ Leukocyte L1 Antigen Complex - metabolism
/ Leukocyte L1 Antigen Complex - pharmacology
/ Liver
/ Liver Abscess - microbiology
/ Metals
/ Mice
/ Rodents
/ Staphylococcal Infections - immunology
/ Staphylococcal Infections - metabolism
/ Staphylococcal Infections - microbiology
/ Staphylococcus aureus - drug effects
/ Staphylococcus aureus - genetics
/ Staphylococcus aureus - growth & development
/ zinc
