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Regulation of monocyte cell fate by blood vessels mediated by Notch signalling
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Regulation of monocyte cell fate by blood vessels mediated by Notch signalling
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Journal Article
Regulation of monocyte cell fate by blood vessels mediated by Notch signalling
2016
Overview
A population of monocytes, known as Ly6C
lo
monocytes, patrol blood vessels by crawling along the vascular endothelium. Here we show that endothelial cells control their origin through Notch signalling. Using combinations of conditional genetic deletion strategies and cell-fate tracking experiments we show that Notch2 regulates conversion of Ly6C
hi
monocytes into Ly6C
lo
monocytes
in vivo
and
in vitro,
thereby regulating monocyte cell fate under steady-state conditions. This process is controlled by Notch ligand delta-like 1 (Dll1) expressed by a population of endothelial cells that constitute distinct vascular niches in the bone marrow and spleen
in vivo
, while culture on recombinant DLL1 induces monocyte conversion
in vitro
. Thus, blood vessels regulate monocyte conversion, a form of committed myeloid cell fate regulation.
Circulating Ly6C
lo
monocytes are thought to be derived from Ly6C
hi
subset. Here the authors show that Notch signalling is activated in Ly6C
lo
cells and is required for their differentiation, and that Notch ligands that initiate this signalling are provided by a subset of endothelial cells.
Publisher
Nature Publishing Group UK,Nature Publishing Group,Nature Portfolio
Subject
/ 13/106
/ 13/21
/ 13/31
/ 13/51
/ 14/19
/ 64/60
/ Animals
/ Bone Marrow Cells - metabolism
/ Endothelial Cells - metabolism
/ GPI-Linked Proteins - metabolism
/ Humanities and Social Sciences
/ Humans
/ Intercellular Signaling Peptides and Proteins - genetics
/ Intercellular Signaling Peptides and Proteins - metabolism
/ Ligands
/ Male
/ Mice
/ Receptor, Notch2 - metabolism
/ Recombinant Proteins - metabolism
/ Science
/ Signal Transduction - physiology
/ Spleen
