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MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells
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MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells
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Journal Article
MiR-133 Targets YES1 and Inhibits the Growth of Triple-Negative Breast Cancer Cells
2020
Overview
Triple-negative breast cancer shows worse outcome compared with other subtypes of breast cancer. The discovery of dysregulated microRNAs and their roles in the progression of triple-negative breast cancer provide novel strategies for the treatment of patients with triple-negative breast cancer. In this study, we identified the significant reduction of miR-133 in triple-negative breast cancer tissues and cell lines. Ectopic overexpression of miR-133 suppressed the proliferation, colony formation, and upregulated the apoptosis of triple-negative breast cancer cells. Mechanism study revealed that the YES Proto-Oncogene 1 was a target of miR-133. miR-133 bound the 3′-untranslated region of YES Proto-Oncogene 1 and decreased the level of YES Proto-Oncogene 1 in triple-negative breast cancer cells. Consistent with miR-133 downregulation, YES1 was significantly increased in triple-negative breast cancer, which was inversely correlated with the level of miR-133. Restoration of YES Proto-Oncogene 1 attenuated the inhibitory effects of miR-133 on the proliferation and colony formation of triple-negative breast cancer cells. Consistent with the decreased expression of YES Proto-Oncogene 1, overexpression of miR-133 suppressed the phosphorylation of YAP1 in triple-negative breast cancer cells. Our results provided novel evidence for the role of miR-133/YES1 axis in the development of triple-negative breast cancer, which indicated miR-133 might be a potential therapeutic strategy for triple-negative breast cancer.
Publisher
SAGE Publications,Sage Publications Ltd,SAGE Publishing
Subject
/ Adaptor Proteins, Signal Transducing - genetics
/ Adaptor Proteins, Signal Transducing - metabolism
/ Biomarkers, Tumor - genetics
/ Biomarkers, Tumor - metabolism
/ Colonies
/ Female
/ Gene Expression Regulation, Neoplastic
/ Humans
/ miRNA
/ Original
/ Proto-Oncogene Proteins c-yes - genetics
/ Proto-Oncogene Proteins c-yes - metabolism
/ Transcription Factors - genetics
/ Transcription Factors - metabolism
/ Triple Negative Breast Neoplasms - genetics
/ Triple Negative Breast Neoplasms - pathology
