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Exploiting the Reversibility of Natural Product Glycosyltransferase-Catalyzed Reactions
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Exploiting the Reversibility of Natural Product Glycosyltransferase-Catalyzed Reactions
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Journal Article
Exploiting the Reversibility of Natural Product Glycosyltransferase-Catalyzed Reactions
2006
Overview
Glycosyltransferases (GTs), an essential class of ubiquitous enzymes, are generally perceived as unidirectional catalysts. In contrast, we report that four glycosyltransferases from two distinct natural product biosynthetic pathways--calicheamicin and vancomycin--readily catalyze reversible reactions, allowing sugars and aglycons to be exchanged with ease. As proof of the broader applicability of these new reactions, more than 70 differentially glycosylated calicheamicin and vancomycin variants are reported. This study suggests the reversibility of GT-catalyzed reactions may be general and useful for generating exotic nucleotide sugars, establishing in vitro GT activity in complex systems, and enhancing natural product diversity.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
Aminoglycosides - biosynthesis
/ Aminoglycosides - metabolism
/ Biological and medical sciences
/ Enzymes
/ Fundamental and applied biological sciences. Psychology
/ Glucosyltransferases - metabolism
/ Glycosyltransferases - genetics
/ Glycosyltransferases - metabolism
/ Nucleoside Diphosphate Sugars - metabolism
/ Sugar
/ Sugars
/ Thymine Nucleotides - metabolism
