Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese

by Zhang, D-F , Yao, Y-G , Wang, D , Li, Y-Y

in 631/208/2489/144 / 631/250/2501 / 631/250/255/1318 / Adolescent / Adult / Antigens, Bacterial - genetics / Association analysis / Biomedical and Life Sciences / Biomedicine / Blood Proteins - genetics / Blood Proteins - metabolism / Cancer Research / Case-Control Studies / Child / China / Complement factor H / Complement Factor H - genetics / Complement Factor H - metabolism / Complement system / Dermatology / Factor H-binding protein / Female / Gene Expression / Gene mapping / Genes / Genetic aspects / Genetic diversity / Genetic variation / Globular proteins / Haplotypes / Homeostasis / Human Genetics / Humans / Identification and classification / Immunology / Leprosy / Leprosy - genetics / Male / Mutation, Missense / Mycobacterium leprae / Mycobacterium leprae - genetics / Pathogens / Polymorphism, Single Nucleotide / Properties / Proteins / Quantitative trait loci / Risk factors / short-communication / Single-nucleotide polymorphism / Zoology

2014

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese

by Zhang, D-F , Yao, Y-G , Wang, D , Li, Y-Y

2014

Confirm

Do you wish to request the book?

Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese

by Zhang, D-F , Yao, Y-G , Wang, D , Li, Y-Y

2014

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Mapping genetic variants in the CFH gene for association with leprosy in Han Chinese

Zhang, D-F,

Yao, Y-G,

Wang, D,

Li, Y-Y

2014

Overview

Complement factor H (CFH) is an essential regulator in the homeostasis of the complement system that plays multiple roles in leprosy. We previously reported a preliminary association of CFH with leprosy, but potentially causal variants remain to be identified. In this study, we performed a fine-mapping association analysis in 1110 individuals (527 leprosy patients and 583 controls) followed by bioinformatic analyses. We identified no association of typical missense CFH variants with leprosy and factor H-binding protein was not detected in Mycobacterium leprae . However, robust associations ( P Bonferroni <0.003) of several CFH intronic tag single-nucleotide polymorphisms with leprosy were observed. Expression quantitative trait locus analysis showed that these leprosy-protective alleles were associated with higher CFH level and lower CFHR3 (complement factor H-related 3) level. Our results indicated that CFH variants may contribute to leprosy pathogenesis through altering CFH expression, leading to regulation of complement activity rather than mediating immune evasion by bacteria binding.

Share this book

Add to My Shelf

Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

/ Adult

/ Antigens, Bacterial - genetics

/ Association analysis