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Impact of puberty on the evolution of cerebral perfusion during adolescence

by Wolf, Daniel H. , Calkins, Monica E. , Elliott, Mark A. , Gennatas, Efstathios D. , Ruparel, Kosha , Roalf, David R. , Erus, Guray , Satterthwaite, Theodore D. , Vandekar, Simon N. , Davatzikos, Christos , Hakonarson, Hakon , Shinohara, Russell T. , Gur, Raquel E. , Jackson, Chad , Gur, Ruben C. , Hopson, Ryan D. , Prabhakaran, Karthik , Detre, John A.

in Adolescence / Adolescent / Adolescents / Biological Sciences / Blood flow / brain / Brain - blood supply / Brain research / Cerebral Arteries - physiology / Cerebrovascular Circulation - physiology / Child / Child development / Cohort Studies / Estrogens / evolution / Female / females / Gray matter / Humans / Imaging / magnetic resonance imaging / Magnetic Resonance Imaging - methods / Male / males / Neurosciences / Perfusion / Prefrontal cortex / Puberty / Puberty - physiology / Sex Factors / Sex linked differences / Spin Labels / Time Factors / Trajectories / Young Adult / youth / youth development

2014

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Impact of puberty on the evolution of cerebral perfusion during adolescence

2014

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2014

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Journal Article

Impact of puberty on the evolution of cerebral perfusion during adolescence

Wolf, Daniel H.,

Calkins, Monica E.,

Elliott, Mark A.,

Gennatas, Efstathios D.,

Ruparel, Kosha,

Roalf, David R.,

Erus, Guray,

Satterthwaite, Theodore D.,

Vandekar, Simon N.,

Davatzikos, Christos,

Hakonarson, Hakon,

Shinohara, Russell T.,

Gur, Raquel E.,

Jackson, Chad,

Gur, Ruben C.,

Hopson, Ryan D.,

Prabhakaran, Karthik,

Detre, John A.

2014

Overview

Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8–22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.

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Publisher

National Academy of Sciences,National Acad Sciences

Subject

Adolescence

/ Adolescent

/ Adolescents

/ Biological Sciences

/ Blood flow

/ brain

/ Brain - blood supply