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Ability of human CDC25B phosphatase splice variants to replace the function of the fission yeast Cdc25 cell cycle regulator
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Ability of human CDC25B phosphatase splice variants to replace the function of the fission yeast Cdc25 cell cycle regulator
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Ability of human CDC25B phosphatase splice variants to replace the function of the fission yeast Cdc25 cell cycle regulator
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Journal Article
Ability of human CDC25B phosphatase splice variants to replace the function of the fission yeast Cdc25 cell cycle regulator
2004
Overview
CDC25 phosphatases are essential and evolutionary-conserved actors of the eukaryotic cell cycle control. To examine and compare the properties of three splicing variants of human CDC25B, recombinant fission yeast strains expressing the human proteins in place of the endogenous Cdc25 were generated and characterized. We report, that the three CDC25B variants: (i) efficiently replace the yeast counterpart in vegetative growth, (ii) partly restore the γ and UV radiation DNA damage-activated checkpoint, (iii) fail to restore the DNA replication checkpoint activated by hydroxyurea. Although these yeast strains do not reveal the specific functions of the human CDC25B variants, they should provide useful screening tools for the identification of new cell cycle regulators and pharmacological inhibitors of CDC25 phosphatase.
Publisher
Elsevier B.V,Blackwell Publishing Ltd,Oxford University Press (OUP)
Subject
/ CDC25
/ cdc25 Phosphatases - genetics
/ cdc25 Phosphatases - metabolism
/ cdc25 Phosphatases - physiology
/ Cell Cycle Proteins - genetics
/ Cell Cycle Proteins - metabolism
/ Cell Cycle Proteins - physiology
/ DNA Replication - physiology
/ Fungal Proteins - physiology
/ Human
/ Humans
/ ras-GRF1
/ Recombinant Proteins - genetics
/ Recombinant Proteins - metabolism
/ Schizosaccharomyces - cytology
/ Schizosaccharomyces - enzymology
/ Schizosaccharomyces - genetics
