Journal Article

Liver elasticity in healthy individuals by two novel shear-wave elastography systems—Comparison by age, gender, BMI and number of measurements

Mjelle, Anders Batman, Gilja, Odd Helge, Mulabecirovic, Anesa, Havre, Roald Flesland, Vesterhus, Mette

2018

Overview

Establishing normal liver stiffness (LS) values in healthy livers is a prerequisite to differentiate normal from pathological LS values. Our aim was to define normal LS using two novel elastography methods head-to-head and to assess the number of measurements, variability and reproducibility. We evaluated shear wave elastography (SWE) methods integrated in Samsung RS80A and GE S8 by obtaining LS measurements (LSM) in 100 healthy subjects (20-70 years). Transient Elastography (TE) was used as reference method. Data were analyzed according to age, sex, BMI and 5 vs. 10 measurements. All subjects underwent B-mode ultrasound examination and lab tests to exclude liver pathology. Interobserver variation was evaluated in a subset (n = 24). Both methods showed excellent feasibility, measuring LS in all subjects. LSM-mean for GE S8 2D-SWE was higher compared to TE (4.5±0.8 kPa vs. 4.2±1.1, p<0.001) and Samsung RS80A (4.1±0.8 kPa, p<0.001). Both methods showed low intra- and interobserver variation. LSM-mean was significantly higher in males than females using 2D-SWE, while a similar trend for Samsung SWE did not reach significance. No method demonstrated statistical significant difference in LSM across age and BMI groups nor between LSM-mean based on 5 vs. 10 measurements. LSM was performed with high reproducibility in healthy adult livers. LSM-mean was significantly higher for GE S8 2D-SWE compared to Samsung RS80A and TE in healthy livers. Males had higher LSM than females. No method demonstrated statistical significant difference in LSM-mean across age- and non-obese BMI groups. Our results indicate that five LSM may be sufficient for reliable results.

• Publisher: Public Library of Science,Public Library of Science (PLoS)
• Subject: Acoustics / Adult / Age / Age Factors / Aged / Biology and Life Sciences / Body mass / Body Mass Index / Clinical medicine / Cross-Sectional Studies / Data processing / Elasticity / Elasticity Imaging Techniques - instrumentation / Elasticity Imaging Techniques - methods / Fatty liver / Feasibility studies / Female / Females / Gastroenterology / Gender / Hepatitis / Hepatology / Hospitals / Humans / Laboratories / Liver / Liver - diagnostic imaging / Liver diseases / Male / Males / Measurement methods / Medicine / Medicine and Health Sciences / Methods / Middle Aged / People and Places / Population / Reproducibility / Reproducibility of Results / Research and Analysis Methods / Sex Characteristics / Sex differences / Statistical analysis / Stiffness / Ultrasonic imaging / Ultrasound