Journal Article

Recent Asian origin of chytrid fungi causing global amphibian declines

Kosch, Tiffany A., Pasmans, Frank, Hintz, William E., Schmidt, Benedikt R., Cunningham, Andrew A., Fisher, Matthew C., Miaud, Claude, Doherty-Bone, Thomas M., Verster, Ruhan, Aanensen, David M., Wierzbicki, Claudia, Balloux, François, Courtois, Elodie A., Minting, Pete, Toledo, Luís Felipe, Martel, An, Rosa, Gonçalo M., Gower, David J., Lin, Chun-Fu, Vörös, Judit, Zamudio, Kelly R., Garner, Trenton W. J., Brookes, Lola, Skerratt, Lee F., Brankovics, Balázs, Fumagalli, Matteo, James, Timothy Y., Rieux, Adrien, Bataille, Arnaud, Shelton, Jennifer M. G., Clare, Frances, Martin, Michael D., Waldman, Bruce, Loyau, Adeline, Meurling, Sara, Böll, Susanne, Berger, Lee, Höglund, Jacob, Ghosh, Pria, Valenzuela-Sánchez, Andrés, O’Hanlon, Simon J., Bates, Kieran A., Smith, Freya, Soto-Azat, Claudio, Weldon, Ché, Schmeller, Dirk S., Murray, Kris A., Farrer, Rhys A., Spagnoletti, Matteo, Tessa, Giulia, Wombwell, Emma, Gilbert, M. Thomas P., Jenkinson, Thomas S., Wales, Nathan, Webb, Rebecca J., Laurila, Anssi, Alvarado-Rybak, Mario, Bosch, Jaime

2018

Overview

Species in the fungal genus Batrachochytrium are responsible for severe declines in the populations of amphibians globally. The sources of these pathogens have been uncertain. O'Hanlon et al. used genomics on a panel of more than 200 isolates to trace the source of the frog pathogen B. dendrobatidis to a hyperdiverse hotspot in the Korean peninsula (see the Perspective by Lips). Over the past century, the trade in amphibian species has accelerated, and now all lineages of B. dendrobatidis occur in traded amphibians; the fungus has become ubiquitous and is diversifying rapidly. Science , this issue p. 621 ; see also p. 604 The chytrid fungus responsible for global amphibian declines originated in the Korean peninsula and spread during the past century by human trade. Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis , a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, Bd ASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing. Our findings point to East Asia as a geographic hotspot for B. dendrobatidis biodiversity and the original source of these lineages that now parasitize amphibians worldwide.

• Publisher: The American Association for the Advancement of Science,American Association for the Advancement of Science (AAAS)
• Subject: Africa / Americas / Amphibians / Amphibians - microbiology / Animals / Asia / Australia / Batrachochytrium / Biodiversity / Biodiversity hot spots / Chytridiomycota - classification / Chytridiomycota - genetics / Chytridiomycota - isolation & purification / Chytridiomycota - pathogenicity / Environmental Sciences / Europe / Extinction, Biological / Frogs / Fungi / Gene sequencing / Genes, Fungal / Genetic Variation / Hybridization, Genetic / Infectious diseases / Korea / Pathogens / Phylogeny / Population decline / Reptiles & amphibians / Sequence Analysis, DNA / Species / Virulence / Zoology