Asset Details
Do you wish to reserve the book?
B-Cell Dysregulation in Idiopathic Nephrotic Syndrome: What We Know and What We Need to Discover
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
B-Cell Dysregulation in Idiopathic Nephrotic Syndrome: What We Know and What We Need to Discover
Do you wish to request the book?
B-Cell Dysregulation in Idiopathic Nephrotic Syndrome: What We Know and What We Need to Discover
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
B-Cell Dysregulation in Idiopathic Nephrotic Syndrome: What We Know and What We Need to Discover
2022
Overview
The therapeutic efficacy of B-cell depletion by anti-CD20 treatment in pediatric and, more recently, in adult idiopathic nephrotic syndrome patients suggests a key role of B cells in the pathogenesis of the disease. However, their exact role is still unclear. B cells are able to secrete a large variety of antibodies that can protect against infections. However, B-cell dysregulation is well-established in a variety of autoimmune diseases. In parallel with their ability to produce antibodies, pathogenic B cells display altered effector functions by expressing activating surface molecules, which can strongly modify the immune homeostasis, or by producing specific cytokines, which can directly affect either podocyte structure and functions or modulate T-cell homeostasis. Herein, we report the most relevant clinical and experimental evidences of a pathogenic role of B cells in idiopathic nephrotic syndrome. We further highlight similarities and differences between children and adults affected by non-genetic forms of the disease and discuss what needs to be investigated in order to define the exact mechanisms underlying the pathogenic role of B cells and to identify more tailored therapeutic approaches.
Publisher
Frontiers Media SA,Frontiers Media S.A
Subject
/ Adults
/ Antigens
/ B cells
/ B-Lymphocytes - classification
/ Biopsy
/ Cells
/ Child
/ focal segmental glomerulosclerosis (FSGS)
/ Glomerulosclerosis, Focal Segmental - immunology
/ Glomerulosclerosis, Focal Segmental - pathology
/ Humans
/ Idiopathic Nephrotic syndrome (INS)
/ minimal change disease (MCD)
/ Nephrosis, Lipoid - immunology
/ Nephrosis, Lipoid - pathology
/ Nephrotic Syndrome - immunology
/ Nephrotic Syndrome - pathology
/ Plasma
/ Steroids
