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Classification of idiopathic interstitial pneumonias using anti–myxovirus resistance-protein 1 autoantibody

by Tripathi, Lokesh P. , Kumanogoh, Atsushi , Yano, Yukihiro , Minami, Toshiyuki , Hirose, Masaki , Inoue, Yoshikazu , Kimura, Tetsuya , Hirata, Haruhiko , Takeda, Yoshito , Tomiyama, Noriyuki , Kijima, Takashi , Arai, Toru , Honda, Osamu , Takamatsu, Hyota , Yanagawa, Masahiro , Kitaichi, Masanori , Murakami, Akihiro , Hamano, Yoshimasa , Mori, Masahide , Ueda, Ken , Hamasaki, Toshimitsu , Kato, Yasuhiro , Ihara, Shoichi , Nagatomo, Izumi , Nishikawa, Hiroyoshi , Otsuka, Tomoyuki , Kida, Hiroshi , Inoue, Koji , Mizuguchi, Kenji

in 13/109 / 13/51 / 38/79 / 631/114/663/2065 / 692/4017 / 692/420/256/2515 / 692/53/2421 / 692/53/2422 / Adult / Aged / Alveoli / Amino Acyl-tRNA Synthetases - immunology / Antiviral agents / Autoantibodies / Autoantibodies - blood / Biomarkers - blood / Female / Fibrosis / Humanities and Social Sciences / Humans / Idiopathic Interstitial Pneumonias - classification / Idiopathic Interstitial Pneumonias - diagnosis / Idiopathic Interstitial Pneumonias - pathology / Interferon / Lung diseases / Male / Middle Aged / multidisciplinary / Myxovirus resistance proteins / Myxovirus Resistance Proteins - immunology / Pneumonia / Ribonucleic acid / RNA / Sarcoidosis / Science / Steroids / Transfer RNA

2017

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Classification of idiopathic interstitial pneumonias using anti–myxovirus resistance-protein 1 autoantibody

2017

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2017

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Journal Article

Classification of idiopathic interstitial pneumonias using anti–myxovirus resistance-protein 1 autoantibody

Tripathi, Lokesh P.,

Kumanogoh, Atsushi,

Yano, Yukihiro,

Minami, Toshiyuki,

Hirose, Masaki,

Inoue, Yoshikazu,

Kimura, Tetsuya,

Hirata, Haruhiko,

Takeda, Yoshito,

Tomiyama, Noriyuki,

Kijima, Takashi,

Arai, Toru,

Honda, Osamu,

Takamatsu, Hyota,

Yanagawa, Masahiro,

Kitaichi, Masanori,

Murakami, Akihiro,

Hamano, Yoshimasa,

Mori, Masahide,

Ueda, Ken,

Hamasaki, Toshimitsu,

Kato, Yasuhiro,

Ihara, Shoichi,

Nagatomo, Izumi,

Nishikawa, Hiroyoshi,

Otsuka, Tomoyuki,

Kida, Hiroshi,

Inoue, Koji,

Mizuguchi, Kenji

2017

Overview

Chronic fibrosing idiopathic interstitial pneumonia (IIP) can be divided into two main types: idiopathic pulmonary fibrosis (IPF), a steroid-resistant and progressive disease with a median survival of 2–3 years, and idiopathic non-specific interstitial pneumonia (INSIP), a steroid-sensitive and non-progressive autoimmune disease. Although the clinical courses of these two diseases differ, they may be difficult to distinguish at diagnosis. We performed a comprehensive analysis of serum autoantibodies from patients definitively diagnosed with IPF, INSIP, autoimmune pulmonary alveolar proteinosis, and sarcoidosis. We identified disease-specific autoantibodies and enriched KEGG pathways unique to each disease, and demonstrated that IPF and INSIP are serologically distinct. Furthermore, we discovered a new INSIP-specific autoantibody, anti–myxovirus resistance-1 (MX1) autoantibody. Patients positive for anti-MX1 autoantibody constituted 17.5% of all cases of chronic fibrosing IIPs. Notably, patients rarely simultaneously carried the anti-MX1 autoantibody and the anti–aminoacyl-transfer RNA synthetase autoantibody, which is common in chronic fibrosing IIPs. Because MX1 is one of the most important interferon-inducible anti-viral genes, we have not only identified a new diagnostic autoantibody of INSIP but also obtained new insight into the pathology of INSIP, which may be associated with viral infection and autoimmunity.

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Nature Publishing Group UK,Nature Publishing Group

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