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Quinolin-4-ones: Methods of Synthesis and Application in Medicine
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Journal Article
Quinolin-4-ones: Methods of Synthesis and Application in Medicine
2025
Overview
Quinolinones, also called quinolones, are a group of heterocyclic compounds with a broad spectrum of biological activities. These compounds occur naturally in plants and microorganisms but can also be obtained synthetically. The first synthesis of quinolinones took place at the end of the 19th century, and the most recent methods were published just a few years ago. They allow for obtaining an unlimited number of analogs differing in biological properties. In this review, we described the plethora of methods leading to quinolin-4-ones. Several of these compounds have been used as antibiotics for over four decades, but recently, their antiproliferative effects have been of particular interest to researchers. This review summarizes the experimental progress made in the synthetic development of various routes leading to quinoline-4-ones and presents an overview of the structures, their evolution, and their relation to activity.
Publisher
MDPI AG,MDPI
Subject
/ Anti-Bacterial Agents - chemical synthesis
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Antineoplastic Agents - chemical synthesis
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - pharmacology
/ Cancer
/ Enzymes
/ Humans
/ Melanoma
/ Methods
/ Quinolone antibacterial agents
/ Quinolones - chemical synthesis
/ Review
