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Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery
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Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery
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Journal Article
Water-dispersible PEG-curcumin/amine-functionalized covalent organic framework nanocomposites as smart carriers for in vivo drug delivery
2018
Overview
Covalent organic frameworks (COFs) as drug-delivery carriers have been mostly evaluated in vitro due to the lack of COFs nanocarriers that are suitable for in vivo studies. Here we develop a series of water-dispersible polymer-COF nanocomposites through the assembly of polyethylene-glycol-modified monofunctional curcumin derivatives (PEG-CCM) and amine-functionalized COFs (APTES-COF-1) for in vitro and in vivo drug delivery. The real-time fluorescence response shows efficient tracking of the COF-based materials upon cellular uptake and anticancer drug (doxorubicin (DOX)) release. Notably, in vitro and in vivo studies demonstrate that PEG-CCM@APTES-COF-1 is a smart carrier for drug delivery with superior stability, intrinsic biodegradability, high DOX loading capacity, strong and stable fluorescence, prolonged circulation time and improved drug accumulation in tumors. More intriguingly, PEG
-CCM@APTES-COF-1 presents an effective targeting strategy for brain research. We envisage that PEG-CCM@APTES-COF-1 nanocomposites represent a great promise toward the development of a multifunctional platform for cancer-targeted in vivo drug delivery.
Publisher
Nature Publishing Group,Nature Publishing Group UK,Nature Portfolio
Subject
/ Animals
/ Antibiotics, Antineoplastic - chemistry
/ Antibiotics, Antineoplastic - pharmacology
/ Brain
/ Cancer
/ Carriers
/ Curcumin
/ Female
/ Humans
/ Metal-Organic Frameworks - chemistry
/ Mice
/ Nanocomposites - administration & dosage
/ Polyethylene Glycols - chemistry
/ Tumors
/ Uterine Cervical Neoplasms - metabolism
/ Uterine Cervical Neoplasms - pathology
