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Synapse-specific astrocyte gating of amygdala-related behavior
by
Benneyworth, Michael A
, Araque, Alfonso
, Marsicano, Giovanni
, Martin-Fernandez, Mario
, Robin, Laurie M
, Aguilar, Juan
, Martin, Eduardo D
, Jamison, Stephanie
, Zhao, Zhe
in
6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology
/ Activation
/ Adenosine A2 Receptor Antagonists - pharmacology
/ Amygdala
/ Amygdala - cytology
/ Amygdala - drug effects
/ Amygdala - physiology
/ Animal behavior
/ Animals
/ Anxiety
/ Astrocytes
/ Astrocytes - drug effects
/ Astrocytes - physiology
/ Brain research
/ Channel gating
/ Fear
/ Fear - drug effects
/ Fear - physiology
/ Fear - psychology
/ Firing rate
/ Male
/ Maze Learning - drug effects
/ Maze Learning - physiology
/ Mice
/ Mice, Inbred C57BL
/ Mice, Knockout
/ Nerve Net - cytology
/ Nerve Net - drug effects
/ Nerve Net - physiology
/ Neural networks
/ Neural transmission
/ Neurons
/ Organ Culture Techniques
/ Properties
/ Receptor mechanisms
/ Receptor, Adenosine A2A - physiology
/ Signaling
/ Synapses
/ Synapses - drug effects
/ Synapses - physiology
/ Synaptic transmission
/ Testing
2017
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Synapse-specific astrocyte gating of amygdala-related behavior
by
Benneyworth, Michael A
, Araque, Alfonso
, Marsicano, Giovanni
, Martin-Fernandez, Mario
, Robin, Laurie M
, Aguilar, Juan
, Martin, Eduardo D
, Jamison, Stephanie
, Zhao, Zhe
in
6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology
/ Activation
/ Adenosine A2 Receptor Antagonists - pharmacology
/ Amygdala
/ Amygdala - cytology
/ Amygdala - drug effects
/ Amygdala - physiology
/ Animal behavior
/ Animals
/ Anxiety
/ Astrocytes
/ Astrocytes - drug effects
/ Astrocytes - physiology
/ Brain research
/ Channel gating
/ Fear
/ Fear - drug effects
/ Fear - physiology
/ Fear - psychology
/ Firing rate
/ Male
/ Maze Learning - drug effects
/ Maze Learning - physiology
/ Mice
/ Mice, Inbred C57BL
/ Mice, Knockout
/ Nerve Net - cytology
/ Nerve Net - drug effects
/ Nerve Net - physiology
/ Neural networks
/ Neural transmission
/ Neurons
/ Organ Culture Techniques
/ Properties
/ Receptor mechanisms
/ Receptor, Adenosine A2A - physiology
/ Signaling
/ Synapses
/ Synapses - drug effects
/ Synapses - physiology
/ Synaptic transmission
/ Testing
2017
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While trying to remove the title from your shelf something went wrong :( Kindly try again later!
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Synapse-specific astrocyte gating of amygdala-related behavior
by
Benneyworth, Michael A
, Araque, Alfonso
, Marsicano, Giovanni
, Martin-Fernandez, Mario
, Robin, Laurie M
, Aguilar, Juan
, Martin, Eduardo D
, Jamison, Stephanie
, Zhao, Zhe
in
6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology
/ Activation
/ Adenosine A2 Receptor Antagonists - pharmacology
/ Amygdala
/ Amygdala - cytology
/ Amygdala - drug effects
/ Amygdala - physiology
/ Animal behavior
/ Animals
/ Anxiety
/ Astrocytes
/ Astrocytes - drug effects
/ Astrocytes - physiology
/ Brain research
/ Channel gating
/ Fear
/ Fear - drug effects
/ Fear - physiology
/ Fear - psychology
/ Firing rate
/ Male
/ Maze Learning - drug effects
/ Maze Learning - physiology
/ Mice
/ Mice, Inbred C57BL
/ Mice, Knockout
/ Nerve Net - cytology
/ Nerve Net - drug effects
/ Nerve Net - physiology
/ Neural networks
/ Neural transmission
/ Neurons
/ Organ Culture Techniques
/ Properties
/ Receptor mechanisms
/ Receptor, Adenosine A2A - physiology
/ Signaling
/ Synapses
/ Synapses - drug effects
/ Synapses - physiology
/ Synaptic transmission
/ Testing
2017
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Synapse-specific astrocyte gating of amygdala-related behavior
Journal Article
Synapse-specific astrocyte gating of amygdala-related behavior
2017
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Overview
The amygdala plays key roles in fear and anxiety. Studies of the amygdala have largely focused on neuronal function and connectivity. Astrocytes functionally interact with neurons, but their role in the amygdala remains largely unknown. We show that astrocytes in the medial subdivision of the central amygdala (CeM) determine the synaptic and behavioral outputs of amygdala circuits. To investigate the role of astrocytes in amygdala-related behavior and identify the underlying synaptic mechanisms, we used exogenous or endogenous signaling to selectively activate CeM astrocytes. Astrocytes depressed excitatory synapses from basolateral amygdala via A
adenosine receptor activation and enhanced inhibitory synapses from the lateral subdivision of the central amygdala via A
receptor activation. Furthermore, astrocytic activation decreased the firing rate of CeM neurons and reduced fear expression in a fear-conditioning paradigm. Therefore, we conclude that astrocyte activity determines fear responses by selectively regulating specific synapses, which indicates that animal behavior results from the coordinated activity of neurons and astrocytes.
Publisher
Nature Publishing Group
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