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Antimicrobial Treatment in Diabetic Women with Asymptomatic Bacteriuria
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Antimicrobial Treatment in Diabetic Women with Asymptomatic Bacteriuria
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Journal Article
Antimicrobial Treatment in Diabetic Women with Asymptomatic Bacteriuria
2002
Overview
In women with diabetes, treatment of asymptomatic bacteriuria has been recommended to prevent complications. In this trial, 55 women with diabetes and asymptomatic bacteriuria were randomly assigned to receive antimicrobial therapy and 50 to receive placebo. After a mean follow-up of 27 months, the rates of symptomatic urinary tract infection were similar: 42 percent in the treated group and 40 percent in the placebo group. There were also no significant differences between the two groups in the rates of pyelonephritis or hospitalization for urinary tract infection, although the 95 percent confidence intervals for these differences were wide.
Urinary tract infection is a common clinical problem in women with diabetes mellitus. Such women probably have a higher frequency of symptomatic infection than do women without diabetes,
1
and they also have more severe infections, with an increased risk of hospitalization for pyelonephritis
2
and a higher frequency of bacteremia
3
and bilateral renal involvement.
4
Serious, but uncommon, complications of urinary tract infection, including emphysematous cystitis
5
and pyelonephritis,
6
and intrarenal
7
and perinephric
8
abscess, occur primarily in patients with diabetes.
Asymptomatic bacteriuria is three times as common among women with diabetes as among women without this condition.
9
In the United States, some groups . . .
Publisher
Massachusetts Medical Society
Subject
Anti-Infective Agents, Urinary - therapeutic use
/ Associated diseases and complications
/ Biological and medical sciences
/ Cystitis - prevention & control
/ Diabetes
/ Diabetes. Impaired glucose tolerance
/ Endocrine pancreas. Apud cells (diseases)
/ Female
/ Humans
/ Pyelonephritis - prevention & control
/ Sulfamethizole - therapeutic use
/ Trimethoprim - therapeutic use
/ Urinary Tract Infections - etiology
/ Urinary Tract Infections - prevention & control
/ Women
