Journal Article

The role of 5-HT receptors in depression

Samuels, Benjamin Adam, Yohn, Christine N., Gergues, Mark M.

2017

Overview

Depression is a polygenic and highly complex psychiatric disorder that remains a major burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), are some of the most commonly prescribed drugs worldwide. In this review, we will discuss the evidence that links serotonin and serotonin receptors to the etiology of depression and the mechanisms underlying response to antidepressant treatment. We will then revisit the role of serotonin in three distinct hypotheses that have been proposed over the last several decades to explain the pathophysiology of depression: the monoamine, neurotrophic, and neurogenic hypotheses. Finally, we will discuss how recent studies into serotonin receptors have implicated specific neural circuitry in mediating the antidepressant response, with a focus being placed on the hippocampus.

• Publisher: BioMed Central,BioMed Central Ltd,Springer Nature B.V,BMC
• Subject: 5-HT1A receptor / Animals / Antidepressant / Antidepressants / Anxiety / Behavior / Biomedical and Life Sciences / Biomedicine / Complications and side effects / Dentate gyrus / Depression / Depression (Mood disorder) / Depression - genetics / Depression - metabolism / Development and progression / Dosage and administration / Drug therapy / Drugs / Etiology / Hippocampus / Hippocampus - metabolism / Hippocampus - pathology / Humans / Hypotheses / Illnesses / Mammals / Mental depression / Models, Biological / Molecules of Neural Disorders / Neural networks / Neurogenesis / Neurology / Neurons / Neurosciences / Psychopharmacology / Receptors, Serotonin - genetics / Receptors, Serotonin - metabolism / Review / Rodents / Selective serotonin reuptake inhibitors / Serotonin / Serotonin - genetics / Serotonin - metabolism / Serotonin receptors / Serotonin uptake inhibitors