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Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases
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Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases
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Journal Article
Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases
2017
Overview
We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ 45/61
/ Adult
/ Aged
/ Cardiovascular Diseases - blood
/ Cardiovascular Diseases - chemically induced
/ Cardiovascular Diseases - genetics
/ Female
/ Gene Expression Profiling - methods
/ Gene Expression Regulation - drug effects
/ Gene Regulatory Networks - drug effects
/ Genomes
/ Heme oxygenase (decyclizing)
/ Humanities and Social Sciences
/ Humans
/ Male
/ Medical Genetics and Genomics (including Gene Therapy)
/ Medicinsk genetik och genomik (Här ingår: Genterapi)
/ Medicinska och farmaceutiska grundvetenskaper
/ Science
/ Smoke
/ Thrombin
/ Tobacco
