Asset Details
Do you wish to reserve the book?
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry
Do you wish to request the book?
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry
2012
Overview
Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that blockade of afferent input from the injury with local anesthetic elicits conditioned place preference, activates ventral tegmental dopaminergic cells, and increases dopamine release in the nucleus accumbens. Importantly, place preference is associated with increased activity in midbrain dopaminergic neurons and blocked by dopamine antagonists injected into the nucleus accumbens. The data directly support the hypothesis that relief of pain produces negative reinforcement through activation of the mesolimbic reward-valuation circuitry.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
Afferent Pathways - drug effects
/ Afferent Pathways - physiopathology
/ Anesthetics, Local - administration & dosage
/ Animals
/ Brain
/ Dopamine
/ Dopamine Antagonists - administration & dosage
/ Limbic System - drug effects
/ Limbic System - physiopathology
/ Male
/ Midbrain
/ Neurons
/ Nucleus Accumbens - drug effects
/ Nucleus Accumbens - physiopathology
/ Pain
/ Pain, Postoperative - drug therapy
/ Pain, Postoperative - physiopathology
/ Pain, Postoperative - psychology
/ Rats
/ Reward
/ Surgery
