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The RNA-binding protein Mex3B is a coreceptor of Toll- like receptor 3 in innate antiviral response
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The RNA-binding protein Mex3B is a coreceptor of Toll- like receptor 3 in innate antiviral response
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Journal Article
The RNA-binding protein Mex3B is a coreceptor of Toll- like receptor 3 in innate antiviral response
2016
Overview
Recognition of viral dsRNA by Toll-like receptor 3 （TLR3） leads to induction of interferons （IFNs） and proinflam- matory cytokines, and innate antiviral response. Here we identified the RNA-binding protein Mex3B as a positive regulator of TLR3-mediated signaling by expression cloning screens. Cells from Mex3b-/- mice exhibited reduced production of IFN-β in response to the dsRNA analog poly（I：C） but not infection with RNA viruses. Mex3b-/- mice injected with poly（I：C） was more resistant to poly（I：C）-induced death. Mex3B was associated with TLR3 in the endo- somes. It bound to dsRNA and increased the dsRNA-binding activity ofTLR3. Mex3B also promoted the proteolytic processing of TLR3, which is critical for its activation. Mutants of Mex3B lacking its RNA-binding activity inhibited TLR3-mediated IFN-β induction. These findings suggest that Mex3B acts as a coreceptor of TLR3 in innate antivirai response.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adaptor Proteins, Vesicular Transport - metabolism
/ Animals
/ Biomedical and Life Sciences
/ Cloning
/ dsRNA
/ Female
/ IFN-γ
/ Male
/ Original
/ RNA, Double-Stranded - metabolism
/ RNA-Binding Proteins - genetics
/ RNA-Binding Proteins - metabolism
/ RNA-Binding Proteins - physiology
/ RNA结合蛋白
/ Toll-Like Receptor 3 - metabolism
/ Toll样受体
/ 双链RNA
/ 反应
/ 抗病毒
/ 结合活性
