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Implications and challenges of connexin connections to cancer
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Journal Article
Implications and challenges of connexin connections to cancer
2010
Overview
The gap junction proteins connexins have previously been thought of as tumour suppressors. However, more recent evidence challenges this view, as they can also have roles in tumour progression and metastasis. Therefore, might connexins be more accurately classified as conditional tumour suppressors?
The idea that the gap junction family of proteins, connexins, are tumour suppressors has been widely supported through numerous cancer models. However, the paradigm that connexins and enhanced gap junctional intercellular communication is of universal benefit by restricting tumour growth has been challenged by more recent evidence that suggests a role for connexins in facilitating tumour progression and metastasis. Therefore, connexins might be better classified as conditional tumour suppressors that modulate cell proliferation, as well as adhesion and migration.
Publisher
Nature Publishing Group UK,Nature Publishing Group
