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Moderate exercise improves antibody response to influenza immunization in older adults
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Moderate exercise improves antibody response to influenza immunization in older adults
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Journal Article
Moderate exercise improves antibody response to influenza immunization in older adults
2004
Overview
Influenza vaccine efficacy is reduced among adults over age 65 and a significant number of vaccinated elderly may remain susceptible to influenza virus infection. The effect of moderate exercise training on the immune response to influenza immunization was evaluated in this study. Twenty-seven adults ≥age 64 were assigned to an exercise group (
n=14) or a control group (
n=13). The subjects exercised at 65–75% heart rate reserve (HRR), 25–30
min, 3 days per week, for 10 months. Controls did not change activity. Subjects were immunized with trivalent influenza vaccine before and after the exercise intervention. After the exercise intervention, exercisers exhibited a greater mean fold increase (MFI) in antibody titer to influenza A/New Caledonia/20/99 (H1N1) and A/Panama/2007/99 (H3N2) than controls, and a greater Granzyme B activity to A/Panama/2007/99 than controls. These findings suggest that exercise may enhance the mean fold increase in antibody titer in response to influenza immunization if the influenza antigen was contained in the previous year’s vaccine.
Publisher
Elsevier Ltd,Elsevier,Elsevier Limited
Subject
/ Aged
/ Biological and medical sciences
/ Elderly
/ Exercise
/ Female
/ Fundamental and applied biological sciences. Psychology
/ Humans
/ Influenza A virus - immunology
/ Influenza Vaccines - administration & dosage
/ Influenza Vaccines - immunology
/ Influenza, Human - prevention & control
/ Male
/ Serine Endopeptidases - metabolism
/ Vaccines
/ Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
