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Randomized controlled trial of low-volume bowel preparation agents for colonic bowel preparation: 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate
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Randomized controlled trial of low-volume bowel preparation agents for colonic bowel preparation: 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate
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Randomized controlled trial of low-volume bowel preparation agents for colonic bowel preparation: 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate
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Journal Article
Randomized controlled trial of low-volume bowel preparation agents for colonic bowel preparation: 2-L polyethylene glycol with ascorbic acid versus sodium picosulfate with magnesium citrate
2015
Overview
Purpose
Both 2-L polyethylene glycol with ascorbic acid (2-L PEG/Asc) and sodium picosulfate with magnesium citrate (SP/MC) are low-volume combined agents for colonic preparation. The aim of the current study was to compare the preparation adequacy and patient tolerability of 2-L PEG/Asc and SP/MC.
Methods
We performed a prospective randomized controlled study in outpatients undergoing daytime colonoscopy at a tertiary academic hospital. We compared preparation adequacy based on the Boston Bowel Preparation Scale (BBPS), polyp and adenoma detection rate (PDR and ADR), compliance, tolerability for ease and palatability, intention to reuse, and patient satisfaction using a questionnaire between 2-L PEG/Asc and three sachets of SP/MC, both given in a split-dose method.
Results
A total of 388 patients were evaluated based on intention to treat (ITT) and 356 patients per protocol (PP). No significant differences in preparation adequacy were observed in ITT and PP analyses, based on the BBPS (
p
> 0.05). The PDR and ADR were greater than 60 and 40 % in both groups, respectively (
p
> 0.05). Compliance levels were higher in the 2-L PEG/Asc group than in the SP/MC group (
p
< 0.001). Satisfaction (ITT,
p
= 0.014; PP,
p
= 0.032) and palatability (ITT and PP,
p
< 0.001) levels were higher in the SP/MC group than in the 2-L PEG/Asc group, but values for tolerability for ease and intention to reuse were similar in both groups (ITT and PP,
p
> 0.05).
Conclusions
Both 2-L PEG/Asc and SP/MC had adequate bowel cleansing efficacy to satisfy PDR and ADR as quality indicator and had showed similar tolerability.
Publisher
Springer Berlin Heidelberg,Springer,Springer Nature B.V
Subject
/ Aged
/ Ascorbic Acid - administration & dosage
/ Ascorbic Acid - adverse effects
/ Ascorbic Acid - pharmacology
/ Cathartics - administration & dosage
/ Cathartics - adverse effects
/ Citrates - administration & dosage
/ Citric Acid - administration & dosage
/ Citric Acid - adverse effects
/ Colon
/ Female
/ Humans
/ Male
/ Medicine
/ Organometallic Compounds - administration & dosage
/ Organometallic Compounds - adverse effects
/ Organometallic Compounds - pharmacology
/ Patients
/ Picolines - administration & dosage
/ Polyethylene Glycols - administration & dosage
/ Polyethylene Glycols - adverse effects
/ Polyethylene Glycols - pharmacology
/ Polyps
/ Surgery
/ Tumors
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