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Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens
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Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens
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Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens
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Journal Article
Effects of the Dietary Probiotic, Enterococcus faecium NCIMB11181, on the Intestinal Barrier and System Immune Status in Escherichia coli O78-Challenged Broiler Chickens
2019
Overview
The effects of
Enterococcus faecium
on growth, intestinal barrier function, and immune response in
Escherichia coli
O78-challenged broiler chickens were investigated. Three hundred eight 1-day-old Ross male chickens were randomly assigned into three treatment groups: negative control (C),
E. coli
O78-infected positive (EP), and
E. coli
O78-infected with 200 mg/kg
E. faecium
dietary supplementation (EF).
E. faecium
significantly increased the body weight on day 10 (
P
< 0.05) and day 15. Furthermore, these birds had a greater average daily gain compared with the other groups during days 1–10 (
P
< 0.05). The death rate of the EF chickens dramatically declined.
E. faecium
supplementation improved the jejunal villus height and the ratio of villus height to crypt depth (
P
< 0.05) 3 and 7 days post-infection. The mRNA expression of
claudin-1
significantly increased by
E. faecium
(
P
< 0.05) 3 and 7 days post-infection, and
Mucin2
was markedly enhanced (
P
< 0.05) 3 days post-infection.
E. faecium
upregulated the mRNA expression of
PPAR-γ
and
IL-10
(
P
< 0.05) and downregulated that of
NF-κB
,
TLR4
, and
IL-1β
(
P
< 0.05) in the spleen 3 and 7 days post-infection. Lipopolysaccharide stimulation index was markedly enhanced in the EF group (
P
< 0.05) 3 days post-infection. The increased liver
E. coli
number caused by the
E. coli
O78 challenge was significantly reversed by
E. faecium
(
P
< 0.05).
E. faecium
improved growth and reduced the death rate by regulating the immune response and maintaining the intestinal integrity in
E. coli
O78-challenged broiler chickens.
Publisher
Springer US,Springer Nature B.V
Subject
/ Chemistry and Materials Science
/ Chickens
/ E coli
/ Enterococcus faecium - physiology
/ Escherichia coli - physiology
/ Escherichia coli Infections - drug therapy
/ Escherichia coli Infections - immunology
/ Escherichia coli Infections - microbiology
/ Escherichia coli Infections - veterinary
/ IL-1β
/ Intestinal Mucosa - drug effects
/ Intestinal Mucosa - immunology
/ Intestinal Mucosa - microbiology
/ jejunum
/ liver
/ Male
/ males
/ peroxisome proliferator-activated receptor gamma
/ Peroxisome proliferator-activated receptors
/ Poultry
/ Poultry Diseases - drug therapy
/ Poultry Diseases - immunology
/ Poultry Diseases - microbiology
/ Poultry Diseases - mortality
/ Probiotics - administration & dosage
/ Spleen
/ transcription factor NF-kappa B
/ villi
/ Villus
