Asset Details
Do you wish to reserve the book?
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
Do you wish to request the book?
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins
2004
Overview
Lymphatic vessels are essential for immune surveillance, tissue fluid homeostasis and fat absorption. Defects in lymphatic vessel formation or function cause lymphedema. Here we show that the vascular endothelial growth factor C (VEGF-C) is required for the initial steps in lymphatic development. In
Vegfc
−/−
mice, endothelial cells commit to the lymphatic lineage but do not sprout to form lymph vessels. Sprouting was rescued by VEGF-C and VEGF-D but not by VEGF, indicating VEGF receptor 3 specificity. The lack of lymphatic vessels resulted in prenatal death due to fluid accumulation in tissues, and
Vegfc
+/−
mice developed cutaneous lymphatic hypoplasia and lymphedema. Our results indicate that VEGF-C is the paracrine factor essential for lymphangiogenesis, and show that both
Vegfc
alleles are required for normal lymphatic development.
Publisher
Nature Publishing Group US,Nature Publishing Group
Subject
/ Animals
/ Biomedical and Life Sciences
/ blood
/ cells
/ Embryonic and Fetal Development - genetics
/ Embryonic and Fetal Development - physiology
/ Female
/ gene
/ Immunologi inom det medicinska området
/ Immunology in the Medical Area
/ Lymphangiogenesis - genetics
/ Lymphangiogenesis - physiology
/ Lymphatic Vessels - embryology
/ Lymphedema - physiopathology
/ Male
/ Mice
/ Receptors, Vascular Endothelial Growth Factor - physiology
/ vascular endothelial growth factor C
/ Vascular Endothelial Growth Factor C - deficiency
/ Vascular Endothelial Growth Factor C - genetics
/ Vascular Endothelial Growth Factor C - physiology
/ Vascular Endothelial Growth Factor Receptor-3 - genetics
/ Vascular Endothelial Growth Factor Receptor-3 - physiology
/ vegf-c
