Journal Article

MicroRNA Expression in Cytogenetically Normal Acute Myeloid Leukemia

Kolitz, Jonathan E, Whitman, Susan P, Paschka, Peter, Liu, Chang-Gong, Marcucci, Guido, Langer, Christian, Maharry, Kati, Bloomfield, Clara D, Ruppert, Amy S, Powell, Bayard L, Radmacher, Michael D, Carroll, Andrew J, Garzon, Ramiro, Larson, Richard A, Croce, Carlo M, Baldus, Claudia D, Mrózek, Krzysztof, Caligiuri, Michael A, Vukosavljevic, Tamara

2008

Overview

This study outlines the development of a microRNA signature in patients with cytogenetically normal acute myeloid leukemia (AML) with high-risk molecular features. This type of AML constitutes approximately 65% of cases of cytogenetically normal AML and one third of all AML cases involving patients under the age of 60 years. The microRNA signature correlated not only with the clinical outcome but also with the expression of genes encoding proteins of the innate immune system. This study outlines the development of a microRNA signature in patients with cytogenetically normal AML with high-risk molecular features. The microRNA signature correlated not only with the clinical outcome but also with the expression of genes encoding proteins of the innate immune system. In almost half of patients with acute myeloid leukemia (AML), no cytogenetic abnormality is detectable in the leukemic cells. Such patients are in an intermediate-risk prognostic category, 1 but among them are subgroups of patients who have molecular markers associated with either a favorable prognosis or an unfavorable prognosis. 2 Gene-expression profiling can also identify subgroups of patients who have cytogenetically normal AML with different outcomes. 3 – 5 Patients with internal tandem duplication in the fms-related tyrosine kinase 3 gene ( FLT3 -ITD) and those without FLT3 -ITD but with the wild-type nucleophosmin ( NPM1 ) gene are in a high-risk group, whereas . . .

• Publisher: Massachusetts Medical Society
• Subject: Adult / Analysis of Variance / Biological and medical sciences / DNA-Binding Proteins - genetics / DNA-Binding Proteins - metabolism / Female / fms-Like Tyrosine Kinase 3 - genetics / Gene Expression / Gene Expression Profiling / Gene Expression Regulation, Leukemic - genetics / General aspects / Genetic Markers / Genetic Predisposition to Disease / Hematologic and hematopoietic diseases / Humans / Kaplan-Meier Estimate / Kinases / Leukemia / Leukemia, Myeloid, Acute - genetics / Leukemia, Myeloid, Acute - pathology / Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis / Medical research / Medical sciences / MicroRNAs - metabolism / Middle Aged / Mutation / Nuclear Proteins - genetics / Oligonucleotide Array Sequence Analysis / Prognosis / Proportional Hazards Models / RNA Probes / RNA, Neoplasm - metabolism / Trans-Activators - genetics / Trans-Activators - metabolism / Transcriptional Regulator ERG