Journal Article

Acute Copper and Ascorbic Acid Supplementation Inhibits Non-heme Iron Absorption in Humans

Fernando Pizarro, Olivares, Manuel, Constanza Figueroa

2016

Overview

The objective of the study is to determine the effect of copper (Cu) plus the reducing agent ascorbic acid (AA) on the absorption of non-heme iron (Fe). Experimental study with block design in which each subject was his own control. After signing an informed consent, 14 adult women using an effective method of contraception and negative pregnancy test received 0.5 mg Fe, as ferrous sulfate, alone or with Cu, as copper sulfate, plus ascorbic acid (AA/Cu 2/1 molar ratio) at 4/1; 6/1 and 8/1 Cu/Fe molar ratios as an aqueous solution on days 1, 2, 14, and 15 of the study. Fe absorption was assessed by erythrocyte incorporation of iron radioisotopes ⁵⁵Fe and ⁵⁹Fe. Geometric mean (range ± SD) absorption of Fe at 4/1 and 6/1 Cu/Fe molar ratios (and AA/Cu 2/1 molar ratio) and Fe alone was 57.4 % (35.7–92.1 %), 64.2 % (45.8–89.9 %), and 38.8 % (20.4–73.8 %), respectively (ANOVA for repeated measures p 

• Publisher: Springer US,Springer Nature B.V
• Subject: Absorption / Absorption, Physiological - drug effects / Acids / Adult / adults / analysis of variance / aqueous solutions / ascorbic acid / Ascorbic Acid - administration & dosage / Ascorbic Acid - metabolism / Ascorbic Acid - pharmacology / Biochemistry / Biomedical and Life Sciences / Biotechnology / contraception / Copper / Copper - administration & dosage / Copper - metabolism / Copper - pharmacology / copper sulfate / Dietary Supplements / erythrocytes / Female / Ferrous Compounds - blood / Ferrous Compounds - metabolism / ferrous sulfate / Humans / Iron / iron absorption / Iron radioisotopes / Life Sciences / Middle Aged / Nutrition / Oncology / pregnancy / radionuclides / reducing agents / Studies / Sulfates / Variance analysis / Women